Intracellular Binding/Unbinding Kinetics of Approved Drugs to Carbonic Anhydrase II Observed by in-Cell NMR

[Image: see text] Candidate drugs rationally designed in vitro often fail due to low efficacy in vivo caused by low tissue availability or because of unwanted side effects. To overcome the limitations of in vitro rational drug design, the binding of candidate drugs to their target needs to be evalua...

Descripción completa

Detalles Bibliográficos
Autores principales: Luchinat, Enrico, Barbieri, Letizia, Cremonini, Matteo, Nocentini, Alessio, Supuran, Claudiu T., Banci, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7735671/
https://www.ncbi.nlm.nih.gov/pubmed/32955851
http://dx.doi.org/10.1021/acschembio.0c00590

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7735671/
https://www.ncbi.nlm.nih.gov/pubmed/32955851
http://dx.doi.org/10.1021/acschembio.0c00590

Ejemplares similares