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Association and Prediction of Subclinical Atherosclerosis by Nonalcoholic Fatty Liver Disease in Asymptomatic Patients

BACKGROUND: The prevalence of nonalcoholic fatty liver disease (NAFLD) has been increasing in the general population. This study evaluated the association between NAFLD and significant coronary stenosis in asymptomatic adults and evaluated sex-based differences. METHODS: We performed a retrospective...

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Autores principales: Bae, Ye Seul, Ko, Yeon Seo, Yun, Jae Moon, Eo, Ah Young, Kim, HaJin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7735832/
https://www.ncbi.nlm.nih.gov/pubmed/33354557
http://dx.doi.org/10.1155/2020/8820445
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author Bae, Ye Seul
Ko, Yeon Seo
Yun, Jae Moon
Eo, Ah Young
Kim, HaJin
author_facet Bae, Ye Seul
Ko, Yeon Seo
Yun, Jae Moon
Eo, Ah Young
Kim, HaJin
author_sort Bae, Ye Seul
collection PubMed
description BACKGROUND: The prevalence of nonalcoholic fatty liver disease (NAFLD) has been increasing in the general population. This study evaluated the association between NAFLD and significant coronary stenosis in asymptomatic adults and evaluated sex-based differences. METHODS: We performed a retrospective cross-sectional study in participants without previous cardiovascular diseases who visited the Seoul National University Hospital Health Promotion Center for a health checkup between January 1, 2010, and December 31, 2015. NAFLD was diagnosed on sonography, while coronary artery stenosis (CAS) was assessed on coronary computed tomography angiography (CCTA). RESULTS: We obtained 3,693 participants who met the inclusion criteria, and 3,449 of them had no significant stenosis. Among the participants with significant stenosis, the prevalence of NAFLD was 59.4% (145 patients). The prevalence of NAFLD was 47.26% in male participants, which was higher than that in female participants. The association between NAFLD and significant CAS persisted after adjusting for age, body mass index, glycated hemoglobin, and Framingham risk factors. The correlation between NAFLD and significant coronary stenosis appeared to be stronger in women than in men, but the absolute risk was higher in men than in women. CONCLUSION: NAFLD was strongly associated with CAS. We should be alert about an increased cardiovascular risk in patients with NAFLD and more intensively provide primary prevention by performing tests to detect subclinical atherosclerosis.
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spelling pubmed-77358322020-12-21 Association and Prediction of Subclinical Atherosclerosis by Nonalcoholic Fatty Liver Disease in Asymptomatic Patients Bae, Ye Seul Ko, Yeon Seo Yun, Jae Moon Eo, Ah Young Kim, HaJin Can J Gastroenterol Hepatol Research Article BACKGROUND: The prevalence of nonalcoholic fatty liver disease (NAFLD) has been increasing in the general population. This study evaluated the association between NAFLD and significant coronary stenosis in asymptomatic adults and evaluated sex-based differences. METHODS: We performed a retrospective cross-sectional study in participants without previous cardiovascular diseases who visited the Seoul National University Hospital Health Promotion Center for a health checkup between January 1, 2010, and December 31, 2015. NAFLD was diagnosed on sonography, while coronary artery stenosis (CAS) was assessed on coronary computed tomography angiography (CCTA). RESULTS: We obtained 3,693 participants who met the inclusion criteria, and 3,449 of them had no significant stenosis. Among the participants with significant stenosis, the prevalence of NAFLD was 59.4% (145 patients). The prevalence of NAFLD was 47.26% in male participants, which was higher than that in female participants. The association between NAFLD and significant CAS persisted after adjusting for age, body mass index, glycated hemoglobin, and Framingham risk factors. The correlation between NAFLD and significant coronary stenosis appeared to be stronger in women than in men, but the absolute risk was higher in men than in women. CONCLUSION: NAFLD was strongly associated with CAS. We should be alert about an increased cardiovascular risk in patients with NAFLD and more intensively provide primary prevention by performing tests to detect subclinical atherosclerosis. Hindawi 2020-11-30 /pmc/articles/PMC7735832/ /pubmed/33354557 http://dx.doi.org/10.1155/2020/8820445 Text en Copyright © 2020 Ye Seul Bae et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bae, Ye Seul
Ko, Yeon Seo
Yun, Jae Moon
Eo, Ah Young
Kim, HaJin
Association and Prediction of Subclinical Atherosclerosis by Nonalcoholic Fatty Liver Disease in Asymptomatic Patients
title Association and Prediction of Subclinical Atherosclerosis by Nonalcoholic Fatty Liver Disease in Asymptomatic Patients
title_full Association and Prediction of Subclinical Atherosclerosis by Nonalcoholic Fatty Liver Disease in Asymptomatic Patients
title_fullStr Association and Prediction of Subclinical Atherosclerosis by Nonalcoholic Fatty Liver Disease in Asymptomatic Patients
title_full_unstemmed Association and Prediction of Subclinical Atherosclerosis by Nonalcoholic Fatty Liver Disease in Asymptomatic Patients
title_short Association and Prediction of Subclinical Atherosclerosis by Nonalcoholic Fatty Liver Disease in Asymptomatic Patients
title_sort association and prediction of subclinical atherosclerosis by nonalcoholic fatty liver disease in asymptomatic patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7735832/
https://www.ncbi.nlm.nih.gov/pubmed/33354557
http://dx.doi.org/10.1155/2020/8820445
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