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lncRNAs Are Involved in Sevoflurane Anesthesia-Related Brain Function Modulation through Affecting Mitochondrial Function and Aging Process

Long noncoding RNAs (lncRNAs) play important roles in brain function modulation and neurodegenerative diseases. However, whether lncRNA regulations are involved in the mechanisms of perioperative neurocognitive disorders, especially in anesthesia-related brain dysfunction, remain unknown. Therefore,...

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Autores principales: Qu, Yinyin, Li, Hongyi, Shi, Chengmei, Qian, Min, Yang, Ning, Wang, Liwei, Gao, Xingyu, Ni, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7735847/
https://www.ncbi.nlm.nih.gov/pubmed/33354572
http://dx.doi.org/10.1155/2020/8841511
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author Qu, Yinyin
Li, Hongyi
Shi, Chengmei
Qian, Min
Yang, Ning
Wang, Liwei
Gao, Xingyu
Ni, Cheng
author_facet Qu, Yinyin
Li, Hongyi
Shi, Chengmei
Qian, Min
Yang, Ning
Wang, Liwei
Gao, Xingyu
Ni, Cheng
author_sort Qu, Yinyin
collection PubMed
description Long noncoding RNAs (lncRNAs) play important roles in brain function modulation and neurodegenerative diseases. However, whether lncRNA regulations are involved in the mechanisms of perioperative neurocognitive disorders, especially in anesthesia-related brain dysfunction, remain unknown. Therefore, we explored the expression and regulation pattern profiles of lncRNAs in the hippocampus of aged rats after sevoflurane anesthesia. Three lncRNAs and 772 protein-coding genes were identified by microarray analysis and evidenced by in vitro and in vivo experiments as differentially expressed. Functional annotation and differentially expressed- (DE-) lncRNA-mRNA coexpression networks reveal that DE-lncRNAs are associated with mitochondrial dysfunction and oxidative stress, aging-related metabolism alterations, DNA damage, and apoptosis, as well as neurodegenerative features during sevoflurane anesthesia. These results suggest that lncRNAs play roles in general anesthesia-related brain function modulation during the perioperative context and provide insights into the lncRNA-related modulation mechanisms and targets.
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spelling pubmed-77358472020-12-21 lncRNAs Are Involved in Sevoflurane Anesthesia-Related Brain Function Modulation through Affecting Mitochondrial Function and Aging Process Qu, Yinyin Li, Hongyi Shi, Chengmei Qian, Min Yang, Ning Wang, Liwei Gao, Xingyu Ni, Cheng Biomed Res Int Research Article Long noncoding RNAs (lncRNAs) play important roles in brain function modulation and neurodegenerative diseases. However, whether lncRNA regulations are involved in the mechanisms of perioperative neurocognitive disorders, especially in anesthesia-related brain dysfunction, remain unknown. Therefore, we explored the expression and regulation pattern profiles of lncRNAs in the hippocampus of aged rats after sevoflurane anesthesia. Three lncRNAs and 772 protein-coding genes were identified by microarray analysis and evidenced by in vitro and in vivo experiments as differentially expressed. Functional annotation and differentially expressed- (DE-) lncRNA-mRNA coexpression networks reveal that DE-lncRNAs are associated with mitochondrial dysfunction and oxidative stress, aging-related metabolism alterations, DNA damage, and apoptosis, as well as neurodegenerative features during sevoflurane anesthesia. These results suggest that lncRNAs play roles in general anesthesia-related brain function modulation during the perioperative context and provide insights into the lncRNA-related modulation mechanisms and targets. Hindawi 2020-12-05 /pmc/articles/PMC7735847/ /pubmed/33354572 http://dx.doi.org/10.1155/2020/8841511 Text en Copyright © 2020 Yinyin Qu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Qu, Yinyin
Li, Hongyi
Shi, Chengmei
Qian, Min
Yang, Ning
Wang, Liwei
Gao, Xingyu
Ni, Cheng
lncRNAs Are Involved in Sevoflurane Anesthesia-Related Brain Function Modulation through Affecting Mitochondrial Function and Aging Process
title lncRNAs Are Involved in Sevoflurane Anesthesia-Related Brain Function Modulation through Affecting Mitochondrial Function and Aging Process
title_full lncRNAs Are Involved in Sevoflurane Anesthesia-Related Brain Function Modulation through Affecting Mitochondrial Function and Aging Process
title_fullStr lncRNAs Are Involved in Sevoflurane Anesthesia-Related Brain Function Modulation through Affecting Mitochondrial Function and Aging Process
title_full_unstemmed lncRNAs Are Involved in Sevoflurane Anesthesia-Related Brain Function Modulation through Affecting Mitochondrial Function and Aging Process
title_short lncRNAs Are Involved in Sevoflurane Anesthesia-Related Brain Function Modulation through Affecting Mitochondrial Function and Aging Process
title_sort lncrnas are involved in sevoflurane anesthesia-related brain function modulation through affecting mitochondrial function and aging process
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7735847/
https://www.ncbi.nlm.nih.gov/pubmed/33354572
http://dx.doi.org/10.1155/2020/8841511
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