Cargando…

Gene expression network analysis provides potential targets against SARS-CoV-2

Cell entry of SARS-CoV-2, the novel coronavirus causing COVID-19, is facilitated by host cell angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2). We aimed to identify and characterize genes that are co-expressed with ACE2 and TMPRSS2, and to further explore their bi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hernández Cordero, Ana I., Li, Xuan, Yang, Chen Xi, Milne, Stephen, Bossé, Yohan, Joubert, Philippe, Timens, Wim, van den Berge, Maarten, Nickle, David, Hao, Ke, Sin, Don D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736291/ https://www.ncbi.nlm.nih.gov/pubmed/33318519 http://dx.doi.org/10.1038/s41598-020-78818-w

Ejemplares similares

Multi-omics highlights ABO plasma protein as a causal risk factor for COVID-19
por: Hernández Cordero, Ana I., et al.
Publicado: (2021)

SARS-CoV-2 receptor ACE2 gene expression and RAAS inhibitors
por: Milne, Stephen, et al.
Publicado: (2020)

Refining Susceptibility Loci of Chronic Obstructive Pulmonary Disease with Lung eqtls
por: Lamontagne, Maxime, et al.
Publicado: (2013)

Responsiveness to Ipratropium Bromide in Male and Female Patients with Mild to Moderate Chronic Obstructive Pulmonary Disease
por: Li, Xuan, et al.
Publicado: (2017)

Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank
por: Valette, Kim, et al.
Publicado: (2021)

Sulfatase modifying factor 1 (SUMF1) is associated with Chronic Obstructive Pulmonary Disease
por: Weidner, Julie, et al.
Publicado: (2017)

Genetic regulation of gene expression of MIF family members in lung tissue
por: Florez-Sampedro, Laura, et al.
Publicado: (2020)

A Potent Tartrate Resistant Acid Phosphatase Inhibitor to Study the Function of TRAP in Alveolar Macrophages
por: Boorsma, Carian E., et al.
Publicado: (2017)

Smoking increases expression of the SARS-CoV-2 spike protein-binding long ACE2 isoform in bronchial epithelium
por: Pouwels, Simon D., et al.
Publicado: (2023)

Impact of Statins on Gene Expression in Human Lung Tissues
por: Lane, Jérôme, et al.
Publicado: (2015)

Inhaled corticosteroids downregulate SARS-CoV-2-related genes in COPD: results from a randomised controlled trial
por: Milne, Stephen, et al.
Publicado: (2021)

ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study
por: Gill, Dipender, et al.
Publicado: (2020)

Identification of Susceptibility Genes of Adult Asthma in French Canadian Women
por: Bérubé, Jean-Christophe, et al.
Publicado: (2016)

Human Lung Tissue Transcriptome: Influence of Sex and Age
por: Dugo, Matteo, et al.
Publicado: (2016)

Can ACE2 expression explain SARS‐CoV‐2 infection of the respiratory epithelia in COVID‐19?
por: Nawijn, Martijn C, et al.
Publicado: (2020)

Recent advances in chronic obstructive pulmonary disease pathogenesis: from disease mechanisms to precision medicine
por: Brandsma, Corry‐Anke, et al.
Publicado: (2019)

The Overlap of Lung Tissue Transcriptome of Smoke Exposed Mice with Human Smoking and COPD
por: Obeidat, Ma’en, et al.
Publicado: (2018)

Correction: Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma
por: Hao, Ke, et al.
Publicado: (2012)

Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma
por: Hao, Ke, et al.
Publicado: (2012)

Tobacco Smoking Increases the Lung Gene Expression of ACE2, the Receptor of SARS-CoV-2
por: Cai, Guoshuai, et al.
Publicado: (2020)

BCG vaccination provides protection against IAV but not SARS-CoV-2
por: Kaufmann, Eva, et al.
Publicado: (2022)

High miR203a-3p and miR-375 expression in the airways of smokers with and without COPD
por: van Nijnatten, Jos, et al.
Publicado: (2022)

Performance of an RNA-Based Next-Generation Sequencing Assay for Combined Detection of Clinically Actionable Fusions and Hotspot Mutations in NSCLC
por: Desmeules, Patrice, et al.
Publicado: (2022)

Tumor-based gene expression biomarkers to predict survival following curative intent resection for stage I lung adenocarcinoma
por: Clemenceau, Alisson, et al.
Publicado: (2018)

COPD-derived fibroblasts secrete higher levels of senescence-associated secretory phenotype proteins
por: Woldhuis, Roy R, et al.
Publicado: (2021)

A Simplified Version of the IASLC Grading System for Invasive Pulmonary Adenocarcinomas With Improved Prognosis Discrimination
por: Bossé, Yohan, et al.
Publicado: (2023)

Comparison of genome-wide gene expression profiling by RNA Sequencing versus microarray in bronchial biopsies of COPD patients before and after inhaled corticosteroid treatment: does it provide new insights?
por: Ditz, Benedikt, et al.
Publicado: (2021)

Unravelling actionable biology using transcriptomic data to integrate mitotic index and Ki-67 in the management of lung neuroendocrine tumors
por: Manem, Venkata S.K., et al.
Publicado: (2021)

Addendum: Unravelling actionable biology using transcriptomic data to integrate mitotic index and Ki-67 in the management of lung neuroendocrine tumors
por: Manem, Venkata S.K., et al.
Publicado: (2022)

MicroRNAs Associated with Chronic Mucus Hypersecretion in COPD Are Involved in Fibroblast–Epithelium Crosstalk
por: Tasena, Hataitip, et al.
Publicado: (2022)

Clotting in COVID-19: Is It All in the Genes?
por: Hernandez Cordero, Ana I., et al.
Publicado: (2021)

Updates on the COPD gene list
por: Bossé, Yohan
Publicado: (2012)

microRNA profiling in lung tissue and bronchoalveolar lavage of cigarette smoke-exposed mice and in COPD patients: a translational approach
por: Conickx, Griet, et al.
Publicado: (2017)

Impact of Cigarette Smoke on the Human and Mouse Lungs: A Gene-Expression Comparison Study
por: Morissette, Mathieu C., et al.
Publicado: (2014)

Acute Exacerbations of Chronic Lung Disease: Cardiac Considerations
por: Milne, Kate, et al.
Publicado: (2020)

Neutrophilic Asthma Is Associated With Smoking, High Numbers of IRF5+, and Low Numbers of IL10+ Macrophages
por: Turan, Nil, et al.
Publicado: (2021)

Longitudinal Effects of 1-Year Smoking Cessation on Human Bronchial Epithelial Transcriptome
por: Rathnayake, Senani N.H., et al.
Publicado: (2023)

Identification of transforming growth factor-beta-regulated microRNAs and the microRNA-targetomes in primary lung fibroblasts
por: Ong, Jennie, et al.
Publicado: (2017)

Susceptibility to COPD: Differential Proteomic Profiling after Acute Smoking
por: Franciosi, Lorenza, et al.
Publicado: (2014)

Airway gene expression in COPD is dynamic with inhaled corticosteroid treatment and reflects biological pathways associated with disease activity
por: van den Berge, Maarten, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_tq2mu6q7bf503hcepg9a6uepr4