Disulfide stabilization of human norovirus GI.1 virus-like particles focuses immune response toward blockade epitopes

Human noroviruses are non-enveloped, single-strand RNA viruses that cause pandemic outbreaks of acute gastroenteritis. A bivalent vaccine containing GI.1 and GII.4 virus-like particles (VLPs) has been shown to be safe and highly immunogenic, but its efficacy and durability have been limited. Here, w...

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Detalles Bibliográficos
Autores principales: Verardi, Raffaello, Lindesmith, Lisa C., Tsybovsky, Yaroslav, Gorman, Jason, Chuang, Gwo-Yu, Edwards, Caitlin E., Brewer-Jensen, Paul D., Mallory, Michael L., Ou, Li, Schön, Arne, Shi, Wei, Tully, Ena S., Georgiou, George, Baric, Ralph S., Kwong, Peter D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736355/
https://www.ncbi.nlm.nih.gov/pubmed/33318483
http://dx.doi.org/10.1038/s41541-020-00260-w

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