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Genetic ancestry, skin pigmentation, and the risk of cutaneous squamous cell carcinoma in Hispanic/Latino and non-Hispanic white populations

Although cutaneous squamous cell carcinoma (cSCC) is one of the most common malignancies in individuals of European ancestry, the incidence of cSCC in Hispanic/Latinos is also increasing. cSCC has both a genetic and environmental etiology. Here, we examine the role of genetic ancestry, skin pigmenta...

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Autores principales: Jorgenson, Eric, Choquet, Hélène, Yin, Jie, Hoffmann, Thomas J., Banda, Yambazi, Kvale, Mark N., Risch, Neil, Schaefer, Catherine, Asgari, Maryam M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736583/
https://www.ncbi.nlm.nih.gov/pubmed/33318654
http://dx.doi.org/10.1038/s42003-020-01461-8
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author Jorgenson, Eric
Choquet, Hélène
Yin, Jie
Hoffmann, Thomas J.
Banda, Yambazi
Kvale, Mark N.
Risch, Neil
Schaefer, Catherine
Asgari, Maryam M.
author_facet Jorgenson, Eric
Choquet, Hélène
Yin, Jie
Hoffmann, Thomas J.
Banda, Yambazi
Kvale, Mark N.
Risch, Neil
Schaefer, Catherine
Asgari, Maryam M.
author_sort Jorgenson, Eric
collection PubMed
description Although cutaneous squamous cell carcinoma (cSCC) is one of the most common malignancies in individuals of European ancestry, the incidence of cSCC in Hispanic/Latinos is also increasing. cSCC has both a genetic and environmental etiology. Here, we examine the role of genetic ancestry, skin pigmentation, and sun exposure in Hispanic/Latinos and non-Hispanic whites on cSCC risk. We observe an increased cSCC risk with greater European ancestry (P = 1.27 × 10(−42)) within Hispanic/Latinos and with greater northern (P = 2.38 × 10(−65)) and western (P = 2.28 × 10(−49)) European ancestry within non-Hispanic whites. These associations are significantly, but not completely, attenuated after considering skin pigmentation-associated loci, history of actinic keratosis, and sun-protected versus sun-exposed anatomical sites. We also report an association of the well-known pigment variant Ala111Thr (rs1426654) at SLC24A5 with cSCC in Hispanic/Latinos. These findings demonstrate a strong correlation of northwestern European genetic ancestry with cSCC risk in both Hispanic/Latinos and non-Hispanic whites, largely but not entirely mediated through its impact on skin pigmentation.
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spelling pubmed-77365832020-12-21 Genetic ancestry, skin pigmentation, and the risk of cutaneous squamous cell carcinoma in Hispanic/Latino and non-Hispanic white populations Jorgenson, Eric Choquet, Hélène Yin, Jie Hoffmann, Thomas J. Banda, Yambazi Kvale, Mark N. Risch, Neil Schaefer, Catherine Asgari, Maryam M. Commun Biol Article Although cutaneous squamous cell carcinoma (cSCC) is one of the most common malignancies in individuals of European ancestry, the incidence of cSCC in Hispanic/Latinos is also increasing. cSCC has both a genetic and environmental etiology. Here, we examine the role of genetic ancestry, skin pigmentation, and sun exposure in Hispanic/Latinos and non-Hispanic whites on cSCC risk. We observe an increased cSCC risk with greater European ancestry (P = 1.27 × 10(−42)) within Hispanic/Latinos and with greater northern (P = 2.38 × 10(−65)) and western (P = 2.28 × 10(−49)) European ancestry within non-Hispanic whites. These associations are significantly, but not completely, attenuated after considering skin pigmentation-associated loci, history of actinic keratosis, and sun-protected versus sun-exposed anatomical sites. We also report an association of the well-known pigment variant Ala111Thr (rs1426654) at SLC24A5 with cSCC in Hispanic/Latinos. These findings demonstrate a strong correlation of northwestern European genetic ancestry with cSCC risk in both Hispanic/Latinos and non-Hispanic whites, largely but not entirely mediated through its impact on skin pigmentation. Nature Publishing Group UK 2020-12-14 /pmc/articles/PMC7736583/ /pubmed/33318654 http://dx.doi.org/10.1038/s42003-020-01461-8 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Jorgenson, Eric
Choquet, Hélène
Yin, Jie
Hoffmann, Thomas J.
Banda, Yambazi
Kvale, Mark N.
Risch, Neil
Schaefer, Catherine
Asgari, Maryam M.
Genetic ancestry, skin pigmentation, and the risk of cutaneous squamous cell carcinoma in Hispanic/Latino and non-Hispanic white populations
title Genetic ancestry, skin pigmentation, and the risk of cutaneous squamous cell carcinoma in Hispanic/Latino and non-Hispanic white populations
title_full Genetic ancestry, skin pigmentation, and the risk of cutaneous squamous cell carcinoma in Hispanic/Latino and non-Hispanic white populations
title_fullStr Genetic ancestry, skin pigmentation, and the risk of cutaneous squamous cell carcinoma in Hispanic/Latino and non-Hispanic white populations
title_full_unstemmed Genetic ancestry, skin pigmentation, and the risk of cutaneous squamous cell carcinoma in Hispanic/Latino and non-Hispanic white populations
title_short Genetic ancestry, skin pigmentation, and the risk of cutaneous squamous cell carcinoma in Hispanic/Latino and non-Hispanic white populations
title_sort genetic ancestry, skin pigmentation, and the risk of cutaneous squamous cell carcinoma in hispanic/latino and non-hispanic white populations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736583/
https://www.ncbi.nlm.nih.gov/pubmed/33318654
http://dx.doi.org/10.1038/s42003-020-01461-8
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