Rescuing Over-activated Microglia Restores Cognitive Performance in Juvenile Animals of the Dp(16) Mouse Model of Down Syndrome

Microglia are brain-resident immune cells and regulate mechanisms essential for cognitive functions. Down syndrome (DS), the most frequent cause of genetic intellectual disability, is caused by a supernumerary chromosome 21, containing also genes related to the immune system. In the hippocampus of t...

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Detalles Bibliográficos
Autores principales: Pinto, Bruno, Morelli, Giovanni, Rastogi, Mohit, Savardi, Annalisa, Fumagalli, Amos, Petretto, Andrea, Bartolucci, Martina, Varea, Emilio, Catelani, Tiziano, Contestabile, Andrea, Perlini, Laura E., Cancedda, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736620/
https://www.ncbi.nlm.nih.gov/pubmed/33027640
http://dx.doi.org/10.1016/j.neuron.2020.09.010

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