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Hemolytic Disease of Fetus and Newborn in a Primigravida with Multiple Alloantibodies Involving Anti-Jk(a) and Anti-E: A Case Report
The majority of hemolytic disease of the fetus and newborn (HDFN) reported in the literature is due to ABO and rhesus incompatibility. However, there are also other minor blood groups that have been identified as a cause of HDFN, although the occurrence is much rarer. The antibody screening program...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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OMJ
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736633/ https://www.ncbi.nlm.nih.gov/pubmed/33335745 http://dx.doi.org/10.5001/omj.2020.135 |
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author | Iberahim, Salfarina Aizuddin, Maryam Jameelah Kadir, Nurulhuda Abd Rameli, Nabilah Adzahar, Sumaiyah Noor, Noor Haslina Mohd Abdullah, Wan Zaidah |
author_facet | Iberahim, Salfarina Aizuddin, Maryam Jameelah Kadir, Nurulhuda Abd Rameli, Nabilah Adzahar, Sumaiyah Noor, Noor Haslina Mohd Abdullah, Wan Zaidah |
author_sort | Iberahim, Salfarina |
collection | PubMed |
description | The majority of hemolytic disease of the fetus and newborn (HDFN) reported in the literature is due to ABO and rhesus incompatibility. However, there are also other minor blood groups that have been identified as a cause of HDFN, although the occurrence is much rarer. The antibody screening program for D negative mother and the anti-D immunoglobulin treatment showed a significant reduction of the occurrence of HDFN secondary to anti-D. In a developed country, the screening for red blood cell antibody in the pregnant mother other than anti-D reduced the possibility of HDFN occurrence hence reduced the fetal morbidity and subsequently increased the fetal well being during pregnancy and after the postnatal period. In this case report, we discuss HDFN in a primigravida patient secondary to multiple alloantibodies (anti-Jk(a) and anti-E). The baby developed jaundice with bilirubin levels approaching the exchange transfusion level. However, with extensive phototherapy and immunoglobulin treatment, the child did not require exchange transfusion. We also included the importance of the routine antenatal antibody screening program. This practice will help the transfusion center to find the antigen negative blood in a timely manner and reduce the morbidities and mortalities of HDFN among the newborns. |
format | Online Article Text |
id | pubmed-7736633 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | OMJ |
record_format | MEDLINE/PubMed |
spelling | pubmed-77366332020-12-16 Hemolytic Disease of Fetus and Newborn in a Primigravida with Multiple Alloantibodies Involving Anti-Jk(a) and Anti-E: A Case Report Iberahim, Salfarina Aizuddin, Maryam Jameelah Kadir, Nurulhuda Abd Rameli, Nabilah Adzahar, Sumaiyah Noor, Noor Haslina Mohd Abdullah, Wan Zaidah Oman Med J Case Report The majority of hemolytic disease of the fetus and newborn (HDFN) reported in the literature is due to ABO and rhesus incompatibility. However, there are also other minor blood groups that have been identified as a cause of HDFN, although the occurrence is much rarer. The antibody screening program for D negative mother and the anti-D immunoglobulin treatment showed a significant reduction of the occurrence of HDFN secondary to anti-D. In a developed country, the screening for red blood cell antibody in the pregnant mother other than anti-D reduced the possibility of HDFN occurrence hence reduced the fetal morbidity and subsequently increased the fetal well being during pregnancy and after the postnatal period. In this case report, we discuss HDFN in a primigravida patient secondary to multiple alloantibodies (anti-Jk(a) and anti-E). The baby developed jaundice with bilirubin levels approaching the exchange transfusion level. However, with extensive phototherapy and immunoglobulin treatment, the child did not require exchange transfusion. We also included the importance of the routine antenatal antibody screening program. This practice will help the transfusion center to find the antigen negative blood in a timely manner and reduce the morbidities and mortalities of HDFN among the newborns. OMJ 2020-11-30 /pmc/articles/PMC7736633/ /pubmed/33335745 http://dx.doi.org/10.5001/omj.2020.135 Text en The OMJ is Published Bimonthly and Copyrighted 2020 by the OMSB. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC) 4.0 License. http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Case Report Iberahim, Salfarina Aizuddin, Maryam Jameelah Kadir, Nurulhuda Abd Rameli, Nabilah Adzahar, Sumaiyah Noor, Noor Haslina Mohd Abdullah, Wan Zaidah Hemolytic Disease of Fetus and Newborn in a Primigravida with Multiple Alloantibodies Involving Anti-Jk(a) and Anti-E: A Case Report |
title | Hemolytic Disease of Fetus and Newborn in a Primigravida with Multiple Alloantibodies Involving Anti-Jk(a) and Anti-E: A Case Report |
title_full | Hemolytic Disease of Fetus and Newborn in a Primigravida with Multiple Alloantibodies Involving Anti-Jk(a) and Anti-E: A Case Report |
title_fullStr | Hemolytic Disease of Fetus and Newborn in a Primigravida with Multiple Alloantibodies Involving Anti-Jk(a) and Anti-E: A Case Report |
title_full_unstemmed | Hemolytic Disease of Fetus and Newborn in a Primigravida with Multiple Alloantibodies Involving Anti-Jk(a) and Anti-E: A Case Report |
title_short | Hemolytic Disease of Fetus and Newborn in a Primigravida with Multiple Alloantibodies Involving Anti-Jk(a) and Anti-E: A Case Report |
title_sort | hemolytic disease of fetus and newborn in a primigravida with multiple alloantibodies involving anti-jk(a) and anti-e: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736633/ https://www.ncbi.nlm.nih.gov/pubmed/33335745 http://dx.doi.org/10.5001/omj.2020.135 |
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