Cargando…

Hemolytic Disease of Fetus and Newborn in a Primigravida with Multiple Alloantibodies Involving Anti-Jk(a) and Anti-E: A Case Report

The majority of hemolytic disease of the fetus and newborn (HDFN) reported in the literature is due to ABO and rhesus incompatibility. However, there are also other minor blood groups that have been identified as a cause of HDFN, although the occurrence is much rarer. The antibody screening program...

Descripción completa

Detalles Bibliográficos
Autores principales: Iberahim, Salfarina, Aizuddin, Maryam Jameelah, Kadir, Nurulhuda Abd, Rameli, Nabilah, Adzahar, Sumaiyah, Noor, Noor Haslina Mohd, Abdullah, Wan Zaidah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: OMJ 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736633/
https://www.ncbi.nlm.nih.gov/pubmed/33335745
http://dx.doi.org/10.5001/omj.2020.135
_version_ 1783622804501954560
author Iberahim, Salfarina
Aizuddin, Maryam Jameelah
Kadir, Nurulhuda Abd
Rameli, Nabilah
Adzahar, Sumaiyah
Noor, Noor Haslina Mohd
Abdullah, Wan Zaidah
author_facet Iberahim, Salfarina
Aizuddin, Maryam Jameelah
Kadir, Nurulhuda Abd
Rameli, Nabilah
Adzahar, Sumaiyah
Noor, Noor Haslina Mohd
Abdullah, Wan Zaidah
author_sort Iberahim, Salfarina
collection PubMed
description The majority of hemolytic disease of the fetus and newborn (HDFN) reported in the literature is due to ABO and rhesus incompatibility. However, there are also other minor blood groups that have been identified as a cause of HDFN, although the occurrence is much rarer. The antibody screening program for D negative mother and the anti-D immunoglobulin treatment showed a significant reduction of the occurrence of HDFN secondary to anti-D. In a developed country, the screening for red blood cell antibody in the pregnant mother other than anti-D reduced the possibility of HDFN occurrence hence reduced the fetal morbidity and subsequently increased the fetal well being during pregnancy and after the postnatal period. In this case report, we discuss HDFN in a primigravida patient secondary to multiple alloantibodies (anti-Jk(a) and anti-E). The baby developed jaundice with bilirubin levels approaching the exchange transfusion level. However, with extensive phototherapy and immunoglobulin treatment, the child did not require exchange transfusion. We also included the importance of the routine antenatal antibody screening program. This practice will help the transfusion center to find the antigen negative blood in a timely manner and reduce the morbidities and mortalities of HDFN among the newborns.
format Online
Article
Text
id pubmed-7736633
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher OMJ
record_format MEDLINE/PubMed
spelling pubmed-77366332020-12-16 Hemolytic Disease of Fetus and Newborn in a Primigravida with Multiple Alloantibodies Involving Anti-Jk(a) and Anti-E: A Case Report Iberahim, Salfarina Aizuddin, Maryam Jameelah Kadir, Nurulhuda Abd Rameli, Nabilah Adzahar, Sumaiyah Noor, Noor Haslina Mohd Abdullah, Wan Zaidah Oman Med J Case Report The majority of hemolytic disease of the fetus and newborn (HDFN) reported in the literature is due to ABO and rhesus incompatibility. However, there are also other minor blood groups that have been identified as a cause of HDFN, although the occurrence is much rarer. The antibody screening program for D negative mother and the anti-D immunoglobulin treatment showed a significant reduction of the occurrence of HDFN secondary to anti-D. In a developed country, the screening for red blood cell antibody in the pregnant mother other than anti-D reduced the possibility of HDFN occurrence hence reduced the fetal morbidity and subsequently increased the fetal well being during pregnancy and after the postnatal period. In this case report, we discuss HDFN in a primigravida patient secondary to multiple alloantibodies (anti-Jk(a) and anti-E). The baby developed jaundice with bilirubin levels approaching the exchange transfusion level. However, with extensive phototherapy and immunoglobulin treatment, the child did not require exchange transfusion. We also included the importance of the routine antenatal antibody screening program. This practice will help the transfusion center to find the antigen negative blood in a timely manner and reduce the morbidities and mortalities of HDFN among the newborns. OMJ 2020-11-30 /pmc/articles/PMC7736633/ /pubmed/33335745 http://dx.doi.org/10.5001/omj.2020.135 Text en The OMJ is Published Bimonthly and Copyrighted 2020 by the OMSB. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC) 4.0 License. http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Case Report
Iberahim, Salfarina
Aizuddin, Maryam Jameelah
Kadir, Nurulhuda Abd
Rameli, Nabilah
Adzahar, Sumaiyah
Noor, Noor Haslina Mohd
Abdullah, Wan Zaidah
Hemolytic Disease of Fetus and Newborn in a Primigravida with Multiple Alloantibodies Involving Anti-Jk(a) and Anti-E: A Case Report
title Hemolytic Disease of Fetus and Newborn in a Primigravida with Multiple Alloantibodies Involving Anti-Jk(a) and Anti-E: A Case Report
title_full Hemolytic Disease of Fetus and Newborn in a Primigravida with Multiple Alloantibodies Involving Anti-Jk(a) and Anti-E: A Case Report
title_fullStr Hemolytic Disease of Fetus and Newborn in a Primigravida with Multiple Alloantibodies Involving Anti-Jk(a) and Anti-E: A Case Report
title_full_unstemmed Hemolytic Disease of Fetus and Newborn in a Primigravida with Multiple Alloantibodies Involving Anti-Jk(a) and Anti-E: A Case Report
title_short Hemolytic Disease of Fetus and Newborn in a Primigravida with Multiple Alloantibodies Involving Anti-Jk(a) and Anti-E: A Case Report
title_sort hemolytic disease of fetus and newborn in a primigravida with multiple alloantibodies involving anti-jk(a) and anti-e: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736633/
https://www.ncbi.nlm.nih.gov/pubmed/33335745
http://dx.doi.org/10.5001/omj.2020.135
work_keys_str_mv AT iberahimsalfarina hemolyticdiseaseoffetusandnewborninaprimigravidawithmultiplealloantibodiesinvolvingantijkaandantieacasereport
AT aizuddinmaryamjameelah hemolyticdiseaseoffetusandnewborninaprimigravidawithmultiplealloantibodiesinvolvingantijkaandantieacasereport
AT kadirnurulhudaabd hemolyticdiseaseoffetusandnewborninaprimigravidawithmultiplealloantibodiesinvolvingantijkaandantieacasereport
AT ramelinabilah hemolyticdiseaseoffetusandnewborninaprimigravidawithmultiplealloantibodiesinvolvingantijkaandantieacasereport
AT adzaharsumaiyah hemolyticdiseaseoffetusandnewborninaprimigravidawithmultiplealloantibodiesinvolvingantijkaandantieacasereport
AT noornoorhaslinamohd hemolyticdiseaseoffetusandnewborninaprimigravidawithmultiplealloantibodiesinvolvingantijkaandantieacasereport
AT abdullahwanzaidah hemolyticdiseaseoffetusandnewborninaprimigravidawithmultiplealloantibodiesinvolvingantijkaandantieacasereport