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Cardiopulmonary recovery after COVID-19: an observational prospective multicentre trial

BACKGROUND: After the 2002/2003 severe acute respiratory syndrome outbreak, 30% of survivors exhibited persisting structural pulmonary abnormalities. The long-term pulmonary sequelae of coronavirus disease 2019 (COVID-19) are yet unknown, and comprehensive clinical follow-up data are lacking. METHOD...

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Autores principales: Sonnweber, Thomas, Sahanic, Sabina, Pizzini, Alex, Luger, Anna, Schwabl, Christoph, Sonnweber, Bettina, Kurz, Katharina, Koppelstätter, Sabine, Haschka, David, Petzer, Verena, Boehm, Anna, Aichner, Magdalena, Tymoszuk, Piotr, Lener, Daniela, Theurl, Markus, Lorsbach-Köhler, Almut, Tancevski, Amra, Schapfl, Anna, Schaber, Marc, Hilbe, Richard, Nairz, Manfred, Puchner, Bernhard, Hüttenberger, Doris, Tschurtschenthaler, Christoph, Aßhoff, Malte, Peer, Andreas, Hartig, Frank, Bellmann, Romuald, Joannidis, Michael, Gollmann-Tepeköylü, Can, Holfeld, Johannes, Feuchtner, Gudrun, Egger, Alexander, Hoermann, Gregor, Schroll, Andrea, Fritsche, Gernot, Wildner, Sophie, Bellmann-Weiler, Rosa, Kirchmair, Rudolf, Helbok, Raimund, Prosch, Helmut, Rieder, Dietmar, Trajanoski, Zlatko, Kronenberg, Florian, Wöll, Ewald, Weiss, Günter, Widmann, Gerlig, Löffler-Ragg, Judith, Tancevski, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736754/
https://www.ncbi.nlm.nih.gov/pubmed/33303539
http://dx.doi.org/10.1183/13993003.03481-2020
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author Sonnweber, Thomas
Sahanic, Sabina
Pizzini, Alex
Luger, Anna
Schwabl, Christoph
Sonnweber, Bettina
Kurz, Katharina
Koppelstätter, Sabine
Haschka, David
Petzer, Verena
Boehm, Anna
Aichner, Magdalena
Tymoszuk, Piotr
Lener, Daniela
Theurl, Markus
Lorsbach-Köhler, Almut
Tancevski, Amra
Schapfl, Anna
Schaber, Marc
Hilbe, Richard
Nairz, Manfred
Puchner, Bernhard
Hüttenberger, Doris
Tschurtschenthaler, Christoph
Aßhoff, Malte
Peer, Andreas
Hartig, Frank
Bellmann, Romuald
Joannidis, Michael
Gollmann-Tepeköylü, Can
Holfeld, Johannes
Feuchtner, Gudrun
Egger, Alexander
Hoermann, Gregor
Schroll, Andrea
Fritsche, Gernot
Wildner, Sophie
Bellmann-Weiler, Rosa
Kirchmair, Rudolf
Helbok, Raimund
Prosch, Helmut
Rieder, Dietmar
Trajanoski, Zlatko
Kronenberg, Florian
Wöll, Ewald
Weiss, Günter
Widmann, Gerlig
Löffler-Ragg, Judith
Tancevski, Ivan
author_facet Sonnweber, Thomas
Sahanic, Sabina
Pizzini, Alex
Luger, Anna
Schwabl, Christoph
Sonnweber, Bettina
Kurz, Katharina
Koppelstätter, Sabine
Haschka, David
Petzer, Verena
Boehm, Anna
Aichner, Magdalena
Tymoszuk, Piotr
Lener, Daniela
Theurl, Markus
Lorsbach-Köhler, Almut
Tancevski, Amra
Schapfl, Anna
Schaber, Marc
Hilbe, Richard
Nairz, Manfred
Puchner, Bernhard
Hüttenberger, Doris
Tschurtschenthaler, Christoph
Aßhoff, Malte
Peer, Andreas
Hartig, Frank
Bellmann, Romuald
Joannidis, Michael
Gollmann-Tepeköylü, Can
Holfeld, Johannes
Feuchtner, Gudrun
Egger, Alexander
Hoermann, Gregor
Schroll, Andrea
Fritsche, Gernot
Wildner, Sophie
Bellmann-Weiler, Rosa
Kirchmair, Rudolf
Helbok, Raimund
Prosch, Helmut
Rieder, Dietmar
Trajanoski, Zlatko
Kronenberg, Florian
Wöll, Ewald
Weiss, Günter
Widmann, Gerlig
Löffler-Ragg, Judith
Tancevski, Ivan
author_sort Sonnweber, Thomas
collection PubMed
description BACKGROUND: After the 2002/2003 severe acute respiratory syndrome outbreak, 30% of survivors exhibited persisting structural pulmonary abnormalities. The long-term pulmonary sequelae of coronavirus disease 2019 (COVID-19) are yet unknown, and comprehensive clinical follow-up data are lacking. METHODS: In this prospective, multicentre, observational study, we systematically evaluated the cardiopulmonary damage in subjects recovering from COVID-19 at 60 and 100 days after confirmed diagnosis. We conducted a detailed questionnaire, clinical examination, laboratory testing, lung function analysis, echocardiography and thoracic low-dose computed tomography (CT). RESULTS: Data from 145 COVID-19 patients were evaluated, and 41% of all subjects exhibited persistent symptoms 100 days after COVID-19 onset, with dyspnoea being most frequent (36%). Accordingly, patients still displayed an impaired lung function, with a reduced diffusing capacity in 21% of the cohort being the most prominent finding. Cardiac impairment, including a reduced left ventricular function or signs of pulmonary hypertension, was only present in a minority of subjects. CT scans unveiled persisting lung pathologies in 63% of patients, mainly consisting of bilateral ground-glass opacities and/or reticulation in the lower lung lobes, without radiological signs of pulmonary fibrosis. Sequential follow-up evaluations at 60 and 100 days after COVID-19 onset demonstrated a vast improvement of symptoms and CT abnormalities over time. CONCLUSION: A relevant percentage of post-COVID-19 patients presented with persisting symptoms and lung function impairment along with radiological pulmonary abnormalities >100 days after the diagnosis of COVID-19. However, our results indicate a significant improvement in symptoms and cardiopulmonary status over time.
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spelling pubmed-77367542020-12-15 Cardiopulmonary recovery after COVID-19: an observational prospective multicentre trial Sonnweber, Thomas Sahanic, Sabina Pizzini, Alex Luger, Anna Schwabl, Christoph Sonnweber, Bettina Kurz, Katharina Koppelstätter, Sabine Haschka, David Petzer, Verena Boehm, Anna Aichner, Magdalena Tymoszuk, Piotr Lener, Daniela Theurl, Markus Lorsbach-Köhler, Almut Tancevski, Amra Schapfl, Anna Schaber, Marc Hilbe, Richard Nairz, Manfred Puchner, Bernhard Hüttenberger, Doris Tschurtschenthaler, Christoph Aßhoff, Malte Peer, Andreas Hartig, Frank Bellmann, Romuald Joannidis, Michael Gollmann-Tepeköylü, Can Holfeld, Johannes Feuchtner, Gudrun Egger, Alexander Hoermann, Gregor Schroll, Andrea Fritsche, Gernot Wildner, Sophie Bellmann-Weiler, Rosa Kirchmair, Rudolf Helbok, Raimund Prosch, Helmut Rieder, Dietmar Trajanoski, Zlatko Kronenberg, Florian Wöll, Ewald Weiss, Günter Widmann, Gerlig Löffler-Ragg, Judith Tancevski, Ivan Eur Respir J Original Articles BACKGROUND: After the 2002/2003 severe acute respiratory syndrome outbreak, 30% of survivors exhibited persisting structural pulmonary abnormalities. The long-term pulmonary sequelae of coronavirus disease 2019 (COVID-19) are yet unknown, and comprehensive clinical follow-up data are lacking. METHODS: In this prospective, multicentre, observational study, we systematically evaluated the cardiopulmonary damage in subjects recovering from COVID-19 at 60 and 100 days after confirmed diagnosis. We conducted a detailed questionnaire, clinical examination, laboratory testing, lung function analysis, echocardiography and thoracic low-dose computed tomography (CT). RESULTS: Data from 145 COVID-19 patients were evaluated, and 41% of all subjects exhibited persistent symptoms 100 days after COVID-19 onset, with dyspnoea being most frequent (36%). Accordingly, patients still displayed an impaired lung function, with a reduced diffusing capacity in 21% of the cohort being the most prominent finding. Cardiac impairment, including a reduced left ventricular function or signs of pulmonary hypertension, was only present in a minority of subjects. CT scans unveiled persisting lung pathologies in 63% of patients, mainly consisting of bilateral ground-glass opacities and/or reticulation in the lower lung lobes, without radiological signs of pulmonary fibrosis. Sequential follow-up evaluations at 60 and 100 days after COVID-19 onset demonstrated a vast improvement of symptoms and CT abnormalities over time. CONCLUSION: A relevant percentage of post-COVID-19 patients presented with persisting symptoms and lung function impairment along with radiological pulmonary abnormalities >100 days after the diagnosis of COVID-19. However, our results indicate a significant improvement in symptoms and cardiopulmonary status over time. European Respiratory Society 2021-04-29 /pmc/articles/PMC7736754/ /pubmed/33303539 http://dx.doi.org/10.1183/13993003.03481-2020 Text en Copyright ©ERS 2021 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
spellingShingle Original Articles
Sonnweber, Thomas
Sahanic, Sabina
Pizzini, Alex
Luger, Anna
Schwabl, Christoph
Sonnweber, Bettina
Kurz, Katharina
Koppelstätter, Sabine
Haschka, David
Petzer, Verena
Boehm, Anna
Aichner, Magdalena
Tymoszuk, Piotr
Lener, Daniela
Theurl, Markus
Lorsbach-Köhler, Almut
Tancevski, Amra
Schapfl, Anna
Schaber, Marc
Hilbe, Richard
Nairz, Manfred
Puchner, Bernhard
Hüttenberger, Doris
Tschurtschenthaler, Christoph
Aßhoff, Malte
Peer, Andreas
Hartig, Frank
Bellmann, Romuald
Joannidis, Michael
Gollmann-Tepeköylü, Can
Holfeld, Johannes
Feuchtner, Gudrun
Egger, Alexander
Hoermann, Gregor
Schroll, Andrea
Fritsche, Gernot
Wildner, Sophie
Bellmann-Weiler, Rosa
Kirchmair, Rudolf
Helbok, Raimund
Prosch, Helmut
Rieder, Dietmar
Trajanoski, Zlatko
Kronenberg, Florian
Wöll, Ewald
Weiss, Günter
Widmann, Gerlig
Löffler-Ragg, Judith
Tancevski, Ivan
Cardiopulmonary recovery after COVID-19: an observational prospective multicentre trial
title Cardiopulmonary recovery after COVID-19: an observational prospective multicentre trial
title_full Cardiopulmonary recovery after COVID-19: an observational prospective multicentre trial
title_fullStr Cardiopulmonary recovery after COVID-19: an observational prospective multicentre trial
title_full_unstemmed Cardiopulmonary recovery after COVID-19: an observational prospective multicentre trial
title_short Cardiopulmonary recovery after COVID-19: an observational prospective multicentre trial
title_sort cardiopulmonary recovery after covid-19: an observational prospective multicentre trial
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736754/
https://www.ncbi.nlm.nih.gov/pubmed/33303539
http://dx.doi.org/10.1183/13993003.03481-2020
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