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NAD(+) is not utilized as a co-factor for DNA ligation by human DNA ligase IV
As nucleotidyl transferases, formation of a covalent enzyme-adenylate intermediate is a common first step of all DNA ligases. While it has been shown that eukaryotic DNA ligases utilize ATP as the adenylation donor, it was recently reported that human DNA ligase IV can also utilize NAD(+) and, to a...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736778/ https://www.ncbi.nlm.nih.gov/pubmed/33264406 http://dx.doi.org/10.1093/nar/gkaa1118 |