HK022 bacteriophage Integrase mediated RMCE as a potential tool for human gene therapy

HK022 coliphage site-specific recombinase Integrase (Int) can catalyze integrative site-specific recombination and recombinase-mediated cassette exchange (RMCE) reactions in mammalian cell cultures. Owing to the promiscuity of the 7 bp overlap sequence in its att sites, active ‘attB’ sites flanking...

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Detalles Bibliográficos
Autores principales: Elias, Amer, Kassis, Hala, Elkader, Suha Abd, Gritsenko, Natasha, Nahmad, Alessio, Shir, Hodaya, Younis, Liana, Shannan, Atheer, Aihara, Hideki, Prag, Gali, Yagil, Ezra, Kolot, Mikhail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736782/
https://www.ncbi.nlm.nih.gov/pubmed/33270859
http://dx.doi.org/10.1093/nar/gkaa1140

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