Single-molecule DNA sequencing of widely varying GC-content using nucleotide release, capture and detection in microdroplets

Despite remarkable progress in DNA sequencing technologies there remains a trade-off between short-read platforms, having limited ability to sequence homopolymers, repeated motifs or long-range structural variation, and long-read platforms, which tend to have lower accuracy and/or throughput. Moreov...

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Detalles Bibliográficos
Autores principales: Puchtler, Tim J, Johnson, Kerr, Palmer, Rebecca N, Talbot, Emma L, Ibbotson, Lindsey A, Powalowska, Paulina K, Knox, Rachel, Shibahara, Aya, M. S. Cunha, Pedro, Newell, Oliver J, Wu, Mei, Chana, Jasmin, Athanasopoulou, Evangelia-Nefeli, Waeber, Andreas M, Stolarek, Magdalena, Silva, Ana-Luisa, Mordaka, Justyna M, Haggis-Powell, Michael, Xyrafaki, Christina, Bush, James, Topkaya, Ibrahim S, Sosna, Maciej, Ingham, Richard J, Huckvale, Thomas, Negrea, Aurel, Breiner, Boris, Šlikas, Justinas, Kelly, Douglas J, Dunning, Alexander J, Bell, Neil M, Dethlefsen, Mark, Love, David M, Dear, Paul H, Kuleshova, Jekaterina, Podd, Gareth J, Isaac, Tom H, Balmforth, Barnaby W, Frayling, Cameron A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Methods Online
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736801/
https://www.ncbi.nlm.nih.gov/pubmed/33152076
http://dx.doi.org/10.1093/nar/gkaa987

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