Long-Range Coupled Motions Underlie Ligand Recognition by a Chemokine Receptor

Chemokines are unusual class-A G protein-coupled receptor agonists because of their large size (∼10 kDa) and binding at two distinct receptor sites: N-terminal domain (Site-I, unique to chemokines) and a groove defined by extracellular loop/transmembrane helices (Site-II, shared with all small molec...

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Detalles Bibliográficos
Autores principales: Sepuru, Krishna Mohan, Nair, Vinay, Prakash, Priyanka, Gorfe, Alemayehu A., Rajarathnam, Krishna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736917/
https://www.ncbi.nlm.nih.gov/pubmed/33344917
http://dx.doi.org/10.1016/j.isci.2020.101858

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736917/
https://www.ncbi.nlm.nih.gov/pubmed/33344917
http://dx.doi.org/10.1016/j.isci.2020.101858

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