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Long-Range Coupled Motions Underlie Ligand Recognition by a Chemokine Receptor
Chemokines are unusual class-A G protein-coupled receptor agonists because of their large size (∼10 kDa) and binding at two distinct receptor sites: N-terminal domain (Site-I, unique to chemokines) and a groove defined by extracellular loop/transmembrane helices (Site-II, shared with all small molec...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736917/ https://www.ncbi.nlm.nih.gov/pubmed/33344917 http://dx.doi.org/10.1016/j.isci.2020.101858 |