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Mining database for the expression and clinical significance of STAT family in head and neck squamous cell carcinomas

BACKGROUND: Head and neck squamous cell carcinomas (HNSC) are among the most common malignant tumors with high incidence, relapse, and mortality rate. STAT proteins are implicated in various biological processes, including cell proliferation, metastasis, and immune regulation. METHOD: Various bioinf...

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Autores principales: Ni, Haosheng, Sun, Hui, Zheng, Miaosen, Bian, Tingting, Liu, Jian, Li, Xiaoli, Zhang, Jianguo, Liu, Yifei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736982/
https://www.ncbi.nlm.nih.gov/pubmed/33395750
http://dx.doi.org/10.1016/j.tranon.2020.100976
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author Ni, Haosheng
Sun, Hui
Zheng, Miaosen
Bian, Tingting
Liu, Jian
Li, Xiaoli
Zhang, Jianguo
Liu, Yifei
author_facet Ni, Haosheng
Sun, Hui
Zheng, Miaosen
Bian, Tingting
Liu, Jian
Li, Xiaoli
Zhang, Jianguo
Liu, Yifei
author_sort Ni, Haosheng
collection PubMed
description BACKGROUND: Head and neck squamous cell carcinomas (HNSC) are among the most common malignant tumors with high incidence, relapse, and mortality rate. STAT proteins are implicated in various biological processes, including cell proliferation, metastasis, and immune regulation. METHOD: Various bioinformatics tools were used to explore the role of the STAT family in HNSC. RESULT: The mRNA levels of STAT1/2/4/5A/6 were significantly upregulated in HNSC tissues. The levels of STAT1/2/4/5A/6 could be used for the detection of HNSC. HNSC patients with a high level of STAT5A had a poor overall survival and relapse-free survival. A moderate to high correlation was obtained between the STAT family and HNSC. Genetic alteration revealed that STAT1/2/3/4/5A/5B/6 were altered in 6%, 5%, 7%, 8%, 6%, 6%, and 4% of the queried TCGA HNSC samples, respectively. Immune infiltrations analysis suggested a significant association between STAT5A expression and abundance of specific immune cells. Further, copy number alteration of STAT5A could certainly inhibit infiltration level. Moreover, a close correlation was obtained between STAT5A level and the expression of immune markers in HNSC. Several kinase targets and transcription factor targets of STAT5A in HNSC were also identified. Enrichment analysis suggested that STAT5A and co-expression genes were mainly responsible for adaptive immune response, T cell activation, cytokine-cytokine receptor interaction, chemokine signaling pathway, cell-adhesion molecules, and ribosome and RNA transport. CONCLUSION: Our results provided additional data for the expression and clinical significance of the STAT family in HNSC, and further study should be performed to verify these.
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spelling pubmed-77369822020-12-22 Mining database for the expression and clinical significance of STAT family in head and neck squamous cell carcinomas Ni, Haosheng Sun, Hui Zheng, Miaosen Bian, Tingting Liu, Jian Li, Xiaoli Zhang, Jianguo Liu, Yifei Transl Oncol Original Research BACKGROUND: Head and neck squamous cell carcinomas (HNSC) are among the most common malignant tumors with high incidence, relapse, and mortality rate. STAT proteins are implicated in various biological processes, including cell proliferation, metastasis, and immune regulation. METHOD: Various bioinformatics tools were used to explore the role of the STAT family in HNSC. RESULT: The mRNA levels of STAT1/2/4/5A/6 were significantly upregulated in HNSC tissues. The levels of STAT1/2/4/5A/6 could be used for the detection of HNSC. HNSC patients with a high level of STAT5A had a poor overall survival and relapse-free survival. A moderate to high correlation was obtained between the STAT family and HNSC. Genetic alteration revealed that STAT1/2/3/4/5A/5B/6 were altered in 6%, 5%, 7%, 8%, 6%, 6%, and 4% of the queried TCGA HNSC samples, respectively. Immune infiltrations analysis suggested a significant association between STAT5A expression and abundance of specific immune cells. Further, copy number alteration of STAT5A could certainly inhibit infiltration level. Moreover, a close correlation was obtained between STAT5A level and the expression of immune markers in HNSC. Several kinase targets and transcription factor targets of STAT5A in HNSC were also identified. Enrichment analysis suggested that STAT5A and co-expression genes were mainly responsible for adaptive immune response, T cell activation, cytokine-cytokine receptor interaction, chemokine signaling pathway, cell-adhesion molecules, and ribosome and RNA transport. CONCLUSION: Our results provided additional data for the expression and clinical significance of the STAT family in HNSC, and further study should be performed to verify these. Neoplasia Press 2020-12-10 /pmc/articles/PMC7736982/ /pubmed/33395750 http://dx.doi.org/10.1016/j.tranon.2020.100976 Text en © 2020 Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research
Ni, Haosheng
Sun, Hui
Zheng, Miaosen
Bian, Tingting
Liu, Jian
Li, Xiaoli
Zhang, Jianguo
Liu, Yifei
Mining database for the expression and clinical significance of STAT family in head and neck squamous cell carcinomas
title Mining database for the expression and clinical significance of STAT family in head and neck squamous cell carcinomas
title_full Mining database for the expression and clinical significance of STAT family in head and neck squamous cell carcinomas
title_fullStr Mining database for the expression and clinical significance of STAT family in head and neck squamous cell carcinomas
title_full_unstemmed Mining database for the expression and clinical significance of STAT family in head and neck squamous cell carcinomas
title_short Mining database for the expression and clinical significance of STAT family in head and neck squamous cell carcinomas
title_sort mining database for the expression and clinical significance of stat family in head and neck squamous cell carcinomas
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736982/
https://www.ncbi.nlm.nih.gov/pubmed/33395750
http://dx.doi.org/10.1016/j.tranon.2020.100976
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