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Prevalence and Risk Factors of Substance Use Disorder in Inflammatory Bowel Disease

BACKGROUND: Substance use disorders (SUDs) impose a substantial individual and societal burden; however, the prevalence and associated factors in persons with inflammatory bowel disease (IBD) are largely unknown. We evaluated the prevalence and risk factors of SUD in an IBD cohort. METHODS: Inflamma...

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Autores principales: Carney, Heather, Marrie, Ruth Ann, Bolton, James M, Patten, Scott B, Graff, Lesley A, Bernstein, Charles N, Kowalec, Kaarina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737154/
https://www.ncbi.nlm.nih.gov/pubmed/32025740
http://dx.doi.org/10.1093/ibd/izaa014
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author Carney, Heather
Marrie, Ruth Ann
Bolton, James M
Patten, Scott B
Graff, Lesley A
Bernstein, Charles N
Kowalec, Kaarina
author_facet Carney, Heather
Marrie, Ruth Ann
Bolton, James M
Patten, Scott B
Graff, Lesley A
Bernstein, Charles N
Kowalec, Kaarina
author_sort Carney, Heather
collection PubMed
description BACKGROUND: Substance use disorders (SUDs) impose a substantial individual and societal burden; however, the prevalence and associated factors in persons with inflammatory bowel disease (IBD) are largely unknown. We evaluated the prevalence and risk factors of SUD in an IBD cohort. METHODS: Inflammatory bowel disease participants (n = 247) were recruited via hospital- and community-based gastroenterology clinics, a population-based IBD research registry, and primary care providers as part of a larger cohort study of psychiatric comorbidity in immune-mediated inflammatory diseases. The Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders IV was administered to participants to identify lifetime SUD, anxiety disorder, and major depressive disorder. Additional questionnaires regarding participants’ sociodemographic and clinical characteristics were also completed. We examined demographic and clinical factors associated with lifetime SUD using unadjusted and adjusted logistic regression modeling. RESULTS: Forty-one (16.6%) IBD participants met the criteria for a lifetime diagnosis of an SUD. Factors associated with elevated odds of SUD were ever smoking (adjusted odds ratio [aOR], 2.96; 95% confidence interval [CI], 1.17–7.50), male sex (aOR, 2.44; 95% CI, 1.11–5.36), lifetime anxiety disorder (aOR, 2.41; 95% CI, 1.08–5.37), and higher pain impact (aOR, 1.08; 95% CI, 1.01–1.16). CONCLUSIONS: One in six persons with IBD experienced an SUD, suggesting that clinicians should maintain high index of suspicion regarding possible SUD, and inquiries about substance use should be a part of care for IBD patients, particularly for men, smokers, and patients with anxiety disorders and pain.
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spelling pubmed-77371542020-12-17 Prevalence and Risk Factors of Substance Use Disorder in Inflammatory Bowel Disease Carney, Heather Marrie, Ruth Ann Bolton, James M Patten, Scott B Graff, Lesley A Bernstein, Charles N Kowalec, Kaarina Inflamm Bowel Dis Clinical Research BACKGROUND: Substance use disorders (SUDs) impose a substantial individual and societal burden; however, the prevalence and associated factors in persons with inflammatory bowel disease (IBD) are largely unknown. We evaluated the prevalence and risk factors of SUD in an IBD cohort. METHODS: Inflammatory bowel disease participants (n = 247) were recruited via hospital- and community-based gastroenterology clinics, a population-based IBD research registry, and primary care providers as part of a larger cohort study of psychiatric comorbidity in immune-mediated inflammatory diseases. The Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders IV was administered to participants to identify lifetime SUD, anxiety disorder, and major depressive disorder. Additional questionnaires regarding participants’ sociodemographic and clinical characteristics were also completed. We examined demographic and clinical factors associated with lifetime SUD using unadjusted and adjusted logistic regression modeling. RESULTS: Forty-one (16.6%) IBD participants met the criteria for a lifetime diagnosis of an SUD. Factors associated with elevated odds of SUD were ever smoking (adjusted odds ratio [aOR], 2.96; 95% confidence interval [CI], 1.17–7.50), male sex (aOR, 2.44; 95% CI, 1.11–5.36), lifetime anxiety disorder (aOR, 2.41; 95% CI, 1.08–5.37), and higher pain impact (aOR, 1.08; 95% CI, 1.01–1.16). CONCLUSIONS: One in six persons with IBD experienced an SUD, suggesting that clinicians should maintain high index of suspicion regarding possible SUD, and inquiries about substance use should be a part of care for IBD patients, particularly for men, smokers, and patients with anxiety disorders and pain. Oxford University Press 2020-02-06 /pmc/articles/PMC7737154/ /pubmed/32025740 http://dx.doi.org/10.1093/ibd/izaa014 Text en © 2020 Crohn’s & Colitis Foundation. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Clinical Research
Carney, Heather
Marrie, Ruth Ann
Bolton, James M
Patten, Scott B
Graff, Lesley A
Bernstein, Charles N
Kowalec, Kaarina
Prevalence and Risk Factors of Substance Use Disorder in Inflammatory Bowel Disease
title Prevalence and Risk Factors of Substance Use Disorder in Inflammatory Bowel Disease
title_full Prevalence and Risk Factors of Substance Use Disorder in Inflammatory Bowel Disease
title_fullStr Prevalence and Risk Factors of Substance Use Disorder in Inflammatory Bowel Disease
title_full_unstemmed Prevalence and Risk Factors of Substance Use Disorder in Inflammatory Bowel Disease
title_short Prevalence and Risk Factors of Substance Use Disorder in Inflammatory Bowel Disease
title_sort prevalence and risk factors of substance use disorder in inflammatory bowel disease
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737154/
https://www.ncbi.nlm.nih.gov/pubmed/32025740
http://dx.doi.org/10.1093/ibd/izaa014
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