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The influence of autistic symptoms on social and non-social cognition and on real-life functioning in people with schizophrenia: Evidence from the Italian Network for Research on Psychoses multicenter study

BACKGROUND: Autism spectrum disorders (ASDs) and schizophrenia spectrum disorders (SSDs), although conceptualized as separate entities, may share some clinical and neurobiological features. ASD symptoms may have a relevant role in determining a more severe clinical presentation of schizophrenic diso...

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Autores principales: Vita, Antonio, Barlati, Stefano, Deste, Giacomo, Rocca, Paola, Rossi, Alessandro, Bertolino, Alessandro, Aguglia, Eugenio, Amore, Mario, Bellomo, Antonello, Biondi, Massimo, Carpiniello, Bernardo, Collantoni, Enrico, Cuomo, Alessandro, D’Ambrosio, Enrico, dell’ Osso, Liliana, di Giannantonio, Massimo, Giordano, Giulia Maria, Marchesi, Carlo, Monteleone, Palmiero, Montemagni, Cristiana, Oldani, Lucio, Pompili, Maurizio, Roncone, Rita, Rossi, Rodolfo, Siracusano, Alberto, Zeppegno, Patrizia, Nibbio, Gabriele, Galderisi, Silvana, Maj, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737172/
https://www.ncbi.nlm.nih.gov/pubmed/33168115
http://dx.doi.org/10.1192/j.eurpsy.2020.99
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author Vita, Antonio
Barlati, Stefano
Deste, Giacomo
Rocca, Paola
Rossi, Alessandro
Bertolino, Alessandro
Aguglia, Eugenio
Amore, Mario
Bellomo, Antonello
Biondi, Massimo
Carpiniello, Bernardo
Collantoni, Enrico
Cuomo, Alessandro
D’Ambrosio, Enrico
dell’ Osso, Liliana
di Giannantonio, Massimo
Giordano, Giulia Maria
Marchesi, Carlo
Monteleone, Palmiero
Montemagni, Cristiana
Oldani, Lucio
Pompili, Maurizio
Roncone, Rita
Rossi, Rodolfo
Siracusano, Alberto
Zeppegno, Patrizia
Nibbio, Gabriele
Galderisi, Silvana
Maj, Mario
author_facet Vita, Antonio
Barlati, Stefano
Deste, Giacomo
Rocca, Paola
Rossi, Alessandro
Bertolino, Alessandro
Aguglia, Eugenio
Amore, Mario
Bellomo, Antonello
Biondi, Massimo
Carpiniello, Bernardo
Collantoni, Enrico
Cuomo, Alessandro
D’Ambrosio, Enrico
dell’ Osso, Liliana
di Giannantonio, Massimo
Giordano, Giulia Maria
Marchesi, Carlo
Monteleone, Palmiero
Montemagni, Cristiana
Oldani, Lucio
Pompili, Maurizio
Roncone, Rita
Rossi, Rodolfo
Siracusano, Alberto
Zeppegno, Patrizia
Nibbio, Gabriele
Galderisi, Silvana
Maj, Mario
author_sort Vita, Antonio
collection PubMed
description BACKGROUND: Autism spectrum disorders (ASDs) and schizophrenia spectrum disorders (SSDs), although conceptualized as separate entities, may share some clinical and neurobiological features. ASD symptoms may have a relevant role in determining a more severe clinical presentation of schizophrenic disorder but their relationships with cognitive aspects and functional outcomes of the disease remain to be addressed in large samples of individuals. AIMS: To investigate the clinical, cognitive, and functional correlates of ASD symptoms in a large sample of people diagnosed with schizophrenia. METHODS: The severity of ASD symptoms was measured with the PANSS Autism Severity Scale (PAUSS) in 921 individuals recruited for the Italian Network for Research on Psychoses multicenter study. Based on the PAUSS scores, three groups of subjects were compared on a wide array of cognitive and functional measures. RESULTS: Subjects with more severe ASD symptoms showed a poorer performance in the processing speed (p = 0.010), attention (p = 0.011), verbal memory (p = 0.035), and social cognition (p = 0.001) domains, and an overall lower global cognitive composite score (p = 0.010). Subjects with more severe ASD symptoms also showed poorer functional capacity (p = 0.004), real-world interpersonal relationships (p < 0.001), and participation in community-living activities (p < 0.001). CONCLUSIONS: These findings strengthen the notion that ASD symptoms may have a relevant impact on different aspects of the disease, crucial to the life of people with schizophrenia. Prominent ASD symptoms may characterize a specific subpopulation of individuals with SSD.
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spelling pubmed-77371722020-12-21 The influence of autistic symptoms on social and non-social cognition and on real-life functioning in people with schizophrenia: Evidence from the Italian Network for Research on Psychoses multicenter study Vita, Antonio Barlati, Stefano Deste, Giacomo Rocca, Paola Rossi, Alessandro Bertolino, Alessandro Aguglia, Eugenio Amore, Mario Bellomo, Antonello Biondi, Massimo Carpiniello, Bernardo Collantoni, Enrico Cuomo, Alessandro D’Ambrosio, Enrico dell’ Osso, Liliana di Giannantonio, Massimo Giordano, Giulia Maria Marchesi, Carlo Monteleone, Palmiero Montemagni, Cristiana Oldani, Lucio Pompili, Maurizio Roncone, Rita Rossi, Rodolfo Siracusano, Alberto Zeppegno, Patrizia Nibbio, Gabriele Galderisi, Silvana Maj, Mario Eur Psychiatry Research Article BACKGROUND: Autism spectrum disorders (ASDs) and schizophrenia spectrum disorders (SSDs), although conceptualized as separate entities, may share some clinical and neurobiological features. ASD symptoms may have a relevant role in determining a more severe clinical presentation of schizophrenic disorder but their relationships with cognitive aspects and functional outcomes of the disease remain to be addressed in large samples of individuals. AIMS: To investigate the clinical, cognitive, and functional correlates of ASD symptoms in a large sample of people diagnosed with schizophrenia. METHODS: The severity of ASD symptoms was measured with the PANSS Autism Severity Scale (PAUSS) in 921 individuals recruited for the Italian Network for Research on Psychoses multicenter study. Based on the PAUSS scores, three groups of subjects were compared on a wide array of cognitive and functional measures. RESULTS: Subjects with more severe ASD symptoms showed a poorer performance in the processing speed (p = 0.010), attention (p = 0.011), verbal memory (p = 0.035), and social cognition (p = 0.001) domains, and an overall lower global cognitive composite score (p = 0.010). Subjects with more severe ASD symptoms also showed poorer functional capacity (p = 0.004), real-world interpersonal relationships (p < 0.001), and participation in community-living activities (p < 0.001). CONCLUSIONS: These findings strengthen the notion that ASD symptoms may have a relevant impact on different aspects of the disease, crucial to the life of people with schizophrenia. Prominent ASD symptoms may characterize a specific subpopulation of individuals with SSD. Cambridge University Press 2020-11-10 /pmc/articles/PMC7737172/ /pubmed/33168115 http://dx.doi.org/10.1192/j.eurpsy.2020.99 Text en © The Author(s) 2020 http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Vita, Antonio
Barlati, Stefano
Deste, Giacomo
Rocca, Paola
Rossi, Alessandro
Bertolino, Alessandro
Aguglia, Eugenio
Amore, Mario
Bellomo, Antonello
Biondi, Massimo
Carpiniello, Bernardo
Collantoni, Enrico
Cuomo, Alessandro
D’Ambrosio, Enrico
dell’ Osso, Liliana
di Giannantonio, Massimo
Giordano, Giulia Maria
Marchesi, Carlo
Monteleone, Palmiero
Montemagni, Cristiana
Oldani, Lucio
Pompili, Maurizio
Roncone, Rita
Rossi, Rodolfo
Siracusano, Alberto
Zeppegno, Patrizia
Nibbio, Gabriele
Galderisi, Silvana
Maj, Mario
The influence of autistic symptoms on social and non-social cognition and on real-life functioning in people with schizophrenia: Evidence from the Italian Network for Research on Psychoses multicenter study
title The influence of autistic symptoms on social and non-social cognition and on real-life functioning in people with schizophrenia: Evidence from the Italian Network for Research on Psychoses multicenter study
title_full The influence of autistic symptoms on social and non-social cognition and on real-life functioning in people with schizophrenia: Evidence from the Italian Network for Research on Psychoses multicenter study
title_fullStr The influence of autistic symptoms on social and non-social cognition and on real-life functioning in people with schizophrenia: Evidence from the Italian Network for Research on Psychoses multicenter study
title_full_unstemmed The influence of autistic symptoms on social and non-social cognition and on real-life functioning in people with schizophrenia: Evidence from the Italian Network for Research on Psychoses multicenter study
title_short The influence of autistic symptoms on social and non-social cognition and on real-life functioning in people with schizophrenia: Evidence from the Italian Network for Research on Psychoses multicenter study
title_sort influence of autistic symptoms on social and non-social cognition and on real-life functioning in people with schizophrenia: evidence from the italian network for research on psychoses multicenter study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737172/
https://www.ncbi.nlm.nih.gov/pubmed/33168115
http://dx.doi.org/10.1192/j.eurpsy.2020.99
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