Cargando…
The influence of autistic symptoms on social and non-social cognition and on real-life functioning in people with schizophrenia: Evidence from the Italian Network for Research on Psychoses multicenter study
BACKGROUND: Autism spectrum disorders (ASDs) and schizophrenia spectrum disorders (SSDs), although conceptualized as separate entities, may share some clinical and neurobiological features. ASD symptoms may have a relevant role in determining a more severe clinical presentation of schizophrenic diso...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737172/ https://www.ncbi.nlm.nih.gov/pubmed/33168115 http://dx.doi.org/10.1192/j.eurpsy.2020.99 |
_version_ | 1783622898441781248 |
---|---|
author | Vita, Antonio Barlati, Stefano Deste, Giacomo Rocca, Paola Rossi, Alessandro Bertolino, Alessandro Aguglia, Eugenio Amore, Mario Bellomo, Antonello Biondi, Massimo Carpiniello, Bernardo Collantoni, Enrico Cuomo, Alessandro D’Ambrosio, Enrico dell’ Osso, Liliana di Giannantonio, Massimo Giordano, Giulia Maria Marchesi, Carlo Monteleone, Palmiero Montemagni, Cristiana Oldani, Lucio Pompili, Maurizio Roncone, Rita Rossi, Rodolfo Siracusano, Alberto Zeppegno, Patrizia Nibbio, Gabriele Galderisi, Silvana Maj, Mario |
author_facet | Vita, Antonio Barlati, Stefano Deste, Giacomo Rocca, Paola Rossi, Alessandro Bertolino, Alessandro Aguglia, Eugenio Amore, Mario Bellomo, Antonello Biondi, Massimo Carpiniello, Bernardo Collantoni, Enrico Cuomo, Alessandro D’Ambrosio, Enrico dell’ Osso, Liliana di Giannantonio, Massimo Giordano, Giulia Maria Marchesi, Carlo Monteleone, Palmiero Montemagni, Cristiana Oldani, Lucio Pompili, Maurizio Roncone, Rita Rossi, Rodolfo Siracusano, Alberto Zeppegno, Patrizia Nibbio, Gabriele Galderisi, Silvana Maj, Mario |
author_sort | Vita, Antonio |
collection | PubMed |
description | BACKGROUND: Autism spectrum disorders (ASDs) and schizophrenia spectrum disorders (SSDs), although conceptualized as separate entities, may share some clinical and neurobiological features. ASD symptoms may have a relevant role in determining a more severe clinical presentation of schizophrenic disorder but their relationships with cognitive aspects and functional outcomes of the disease remain to be addressed in large samples of individuals. AIMS: To investigate the clinical, cognitive, and functional correlates of ASD symptoms in a large sample of people diagnosed with schizophrenia. METHODS: The severity of ASD symptoms was measured with the PANSS Autism Severity Scale (PAUSS) in 921 individuals recruited for the Italian Network for Research on Psychoses multicenter study. Based on the PAUSS scores, three groups of subjects were compared on a wide array of cognitive and functional measures. RESULTS: Subjects with more severe ASD symptoms showed a poorer performance in the processing speed (p = 0.010), attention (p = 0.011), verbal memory (p = 0.035), and social cognition (p = 0.001) domains, and an overall lower global cognitive composite score (p = 0.010). Subjects with more severe ASD symptoms also showed poorer functional capacity (p = 0.004), real-world interpersonal relationships (p < 0.001), and participation in community-living activities (p < 0.001). CONCLUSIONS: These findings strengthen the notion that ASD symptoms may have a relevant impact on different aspects of the disease, crucial to the life of people with schizophrenia. Prominent ASD symptoms may characterize a specific subpopulation of individuals with SSD. |
format | Online Article Text |
id | pubmed-7737172 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-77371722020-12-21 The influence of autistic symptoms on social and non-social cognition and on real-life functioning in people with schizophrenia: Evidence from the Italian Network for Research on Psychoses multicenter study Vita, Antonio Barlati, Stefano Deste, Giacomo Rocca, Paola Rossi, Alessandro Bertolino, Alessandro Aguglia, Eugenio Amore, Mario Bellomo, Antonello Biondi, Massimo Carpiniello, Bernardo Collantoni, Enrico Cuomo, Alessandro D’Ambrosio, Enrico dell’ Osso, Liliana di Giannantonio, Massimo Giordano, Giulia Maria Marchesi, Carlo Monteleone, Palmiero Montemagni, Cristiana Oldani, Lucio Pompili, Maurizio Roncone, Rita Rossi, Rodolfo Siracusano, Alberto Zeppegno, Patrizia Nibbio, Gabriele Galderisi, Silvana Maj, Mario Eur Psychiatry Research Article BACKGROUND: Autism spectrum disorders (ASDs) and schizophrenia spectrum disorders (SSDs), although conceptualized as separate entities, may share some clinical and neurobiological features. ASD symptoms may have a relevant role in determining a more severe clinical presentation of schizophrenic disorder but their relationships with cognitive aspects and functional outcomes of the disease remain to be addressed in large samples of individuals. AIMS: To investigate the clinical, cognitive, and functional correlates of ASD symptoms in a large sample of people diagnosed with schizophrenia. METHODS: The severity of ASD symptoms was measured with the PANSS Autism Severity Scale (PAUSS) in 921 individuals recruited for the Italian Network for Research on Psychoses multicenter study. Based on the PAUSS scores, three groups of subjects were compared on a wide array of cognitive and functional measures. RESULTS: Subjects with more severe ASD symptoms showed a poorer performance in the processing speed (p = 0.010), attention (p = 0.011), verbal memory (p = 0.035), and social cognition (p = 0.001) domains, and an overall lower global cognitive composite score (p = 0.010). Subjects with more severe ASD symptoms also showed poorer functional capacity (p = 0.004), real-world interpersonal relationships (p < 0.001), and participation in community-living activities (p < 0.001). CONCLUSIONS: These findings strengthen the notion that ASD symptoms may have a relevant impact on different aspects of the disease, crucial to the life of people with schizophrenia. Prominent ASD symptoms may characterize a specific subpopulation of individuals with SSD. Cambridge University Press 2020-11-10 /pmc/articles/PMC7737172/ /pubmed/33168115 http://dx.doi.org/10.1192/j.eurpsy.2020.99 Text en © The Author(s) 2020 http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Vita, Antonio Barlati, Stefano Deste, Giacomo Rocca, Paola Rossi, Alessandro Bertolino, Alessandro Aguglia, Eugenio Amore, Mario Bellomo, Antonello Biondi, Massimo Carpiniello, Bernardo Collantoni, Enrico Cuomo, Alessandro D’Ambrosio, Enrico dell’ Osso, Liliana di Giannantonio, Massimo Giordano, Giulia Maria Marchesi, Carlo Monteleone, Palmiero Montemagni, Cristiana Oldani, Lucio Pompili, Maurizio Roncone, Rita Rossi, Rodolfo Siracusano, Alberto Zeppegno, Patrizia Nibbio, Gabriele Galderisi, Silvana Maj, Mario The influence of autistic symptoms on social and non-social cognition and on real-life functioning in people with schizophrenia: Evidence from the Italian Network for Research on Psychoses multicenter study |
title | The influence of autistic symptoms on social and non-social cognition and on real-life functioning in people with schizophrenia: Evidence from the Italian Network for Research on Psychoses multicenter study |
title_full | The influence of autistic symptoms on social and non-social cognition and on real-life functioning in people with schizophrenia: Evidence from the Italian Network for Research on Psychoses multicenter study |
title_fullStr | The influence of autistic symptoms on social and non-social cognition and on real-life functioning in people with schizophrenia: Evidence from the Italian Network for Research on Psychoses multicenter study |
title_full_unstemmed | The influence of autistic symptoms on social and non-social cognition and on real-life functioning in people with schizophrenia: Evidence from the Italian Network for Research on Psychoses multicenter study |
title_short | The influence of autistic symptoms on social and non-social cognition and on real-life functioning in people with schizophrenia: Evidence from the Italian Network for Research on Psychoses multicenter study |
title_sort | influence of autistic symptoms on social and non-social cognition and on real-life functioning in people with schizophrenia: evidence from the italian network for research on psychoses multicenter study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737172/ https://www.ncbi.nlm.nih.gov/pubmed/33168115 http://dx.doi.org/10.1192/j.eurpsy.2020.99 |
work_keys_str_mv | AT vitaantonio theinfluenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT barlatistefano theinfluenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT destegiacomo theinfluenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT roccapaola theinfluenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT rossialessandro theinfluenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT bertolinoalessandro theinfluenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT agugliaeugenio theinfluenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT amoremario theinfluenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT bellomoantonello theinfluenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT biondimassimo theinfluenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT carpiniellobernardo theinfluenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT collantonienrico theinfluenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT cuomoalessandro theinfluenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT dambrosioenrico theinfluenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT dellossoliliana theinfluenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT digiannantoniomassimo theinfluenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT giordanogiuliamaria theinfluenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT marchesicarlo theinfluenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT monteleonepalmiero theinfluenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT montemagnicristiana theinfluenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT oldanilucio theinfluenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT pompilimaurizio theinfluenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT ronconerita theinfluenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT rossirodolfo theinfluenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT siracusanoalberto theinfluenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT zeppegnopatrizia theinfluenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT nibbiogabriele theinfluenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT galderisisilvana theinfluenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT majmario theinfluenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT theinfluenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT vitaantonio influenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT barlatistefano influenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT destegiacomo influenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT roccapaola influenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT rossialessandro influenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT bertolinoalessandro influenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT agugliaeugenio influenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT amoremario influenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT bellomoantonello influenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT biondimassimo influenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT carpiniellobernardo influenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT collantonienrico influenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT cuomoalessandro influenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT dambrosioenrico influenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT dellossoliliana influenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT digiannantoniomassimo influenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT giordanogiuliamaria influenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT marchesicarlo influenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT monteleonepalmiero influenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT montemagnicristiana influenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT oldanilucio influenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT pompilimaurizio influenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT ronconerita influenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT rossirodolfo influenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT siracusanoalberto influenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT zeppegnopatrizia influenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT nibbiogabriele influenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT galderisisilvana influenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT majmario influenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy AT influenceofautisticsymptomsonsocialandnonsocialcognitionandonreallifefunctioninginpeoplewithschizophreniaevidencefromtheitaliannetworkforresearchonpsychosesmulticenterstudy |