Selective Elimination of Osteosarcoma Cell Lines with Short Telomeres by Ataxia Telangiectasia and Rad3-Related Inhibitors

[Image: see text] To avoid replicative senescence or telomere-induced apoptosis, cancers employ telomere maintenance mechanisms (TMMs) involving either the upregulation of telomerase or the acquisition of recombination-based alternative telomere lengthening (ALT). The choice of TMM may differentiall...

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Autores principales: Goncalves, Tomas, Zoumpoulidou, Georgia, Alvarez-Mendoza, Carlos, Mancusi, Caterina, Collopy, Laura C., Strauss, Sandra J., Mittnacht, Sibylle, Tomita, Kazunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737214/
https://www.ncbi.nlm.nih.gov/pubmed/33344901
http://dx.doi.org/10.1021/acsptsci.0c00125

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