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A Cas9-mediated adenosine transient reporter enables enrichment of ABE-targeted cells
BACKGROUND: Adenine base editors (ABE) enable single nucleotide modifications without the need for double-stranded DNA breaks (DSBs) induced by conventional CRIPSR/Cas9-based approaches. However, most approaches that employ ABEs require inefficient downstream technologies to identify desired targete...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737295/ https://www.ncbi.nlm.nih.gov/pubmed/33317513 http://dx.doi.org/10.1186/s12915-020-00929-7 |