Probing substrate binding to Metallo-β-Lactamase L1 from Stenotrophomonas maltophilia by using site-directed mutagenesis

BACKGROUND: The metallo-β-lactamases are Zn(II)-containing enzymes that hydrolyze the β-lactam bond in penicillins, cephalosporins, and carbapenems and are involved in bacterial antibiotic resistance. There are at least 20 distinct organisms that produce a metallo-β-lactamase, and these enzymes have...

Descripción completa

Detalles Bibliográficos
Autores principales: Carenbauer, Anne L, Garrity, James D, Periyannan, Gopal, Yates, Robert B, Crowder, Michael W
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC77373/
https://www.ncbi.nlm.nih.gov/pubmed/11876827
http://dx.doi.org/10.1186/1471-2091-3-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC77373/
https://www.ncbi.nlm.nih.gov/pubmed/11876827
http://dx.doi.org/10.1186/1471-2091-3-4

Ejemplares similares