Oxidative stress mediates thalidomide-induced pain by targeting peripheral TRPA1 and central TRPV4

BACKGROUND: The mechanism underlying the pain symptoms associated with chemotherapeutic-induced peripheral neuropathy (CIPN) is poorly understood. Transient receptor potential ankyrin 1 (TRPA1), TRP vanilloid 4 (TRPV4), TRPV1, and oxidative stress have been implicated in several rodent models of CIP...

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Detalles Bibliográficos
Autores principales: De Logu, Francesco, Trevisan, Gabriela, Marone, Ilaria Maddalena, Coppi, Elisabetta, Padilha Dalenogare, Diéssica, Titiz, Mustafa, Marini, Matilde, Landini, Lorenzo, Souza Monteiro de Araujo, Daniel, Li Puma, Simone, Materazzi, Serena, De Siena, Gaetano, Geppetti, Pierangelo, Nassini, Romina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737339/
https://www.ncbi.nlm.nih.gov/pubmed/33317522
http://dx.doi.org/10.1186/s12915-020-00935-9

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