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Oscillometry and computed tomography findings in patients with idiopathic pulmonary fibrosis
Although the utility of oscillometry for predicting disease severity in idiopathic pulmonary fibrosis (IPF) had been researched, little has been reported on the mechanism of why respiratory impedance reflects disease severity. In addition, traction bronchiectasis has been considered to reduce respir...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Respiratory Society
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737428/ https://www.ncbi.nlm.nih.gov/pubmed/33344627 http://dx.doi.org/10.1183/23120541.00391-2020 |
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author | Yamamoto, Yuji Miki, Keisuke Tsujino, Kazuyuki Kuge, Tomoki Okabe, Fukuko Kawasaki, Takahiro Matsuki, Takanori Kagawa, Hiroyuki Miki, Mari Kida, Hiroshi |
author_facet | Yamamoto, Yuji Miki, Keisuke Tsujino, Kazuyuki Kuge, Tomoki Okabe, Fukuko Kawasaki, Takahiro Matsuki, Takanori Kagawa, Hiroyuki Miki, Mari Kida, Hiroshi |
author_sort | Yamamoto, Yuji |
collection | PubMed |
description | Although the utility of oscillometry for predicting disease severity in idiopathic pulmonary fibrosis (IPF) had been researched, little has been reported on the mechanism of why respiratory impedance reflects disease severity. In addition, traction bronchiectasis has been considered to reduce respiratory resistance and correlate negatively with airflow obstruction, but this hypothesis has not been validated. The present study aimed to investigate the correlations between oscillometric parameters and fibrosis-related lung abnormalities in IPF and to assess the utility of oscillometry as a surrogate marker for traction bronchiectasis and airflow obstruction. Eighty Japanese patients with IPF underwent high-resolution computed tomography (HRCT), spirometry, and oscillometry and were retrospectively investigated. Fibrosis-related HRCT findings were scored regarding airspace consolidation, honeycombing, architectural distortion, traction bronchiectasis, and fibrosis. Correlations between the HRCT scores, spirometric parameters, and oscillometric parameters were analysed. Respiratory reactance correlated positively with all fibrosis-related HRCT scores. Vital capacity and forced vital capacity (FVC) correlated negatively with oscillometric parameters and HRCT scores, reflecting the severity of restrictive ventilatory deficiency. Respiratory resistance was not related to any of the HRCT scores or forced expiratory volume in 1 s/FVC. However, forced expiratory volume in 1 s/FVC correlated positively with HRCT scores, which showed that airflow obstruction became milder as the disease progressed. In conclusion, respiratory reactance reflects fibrosis and restrictive ventilatory deficiency in IPF. Moreover, respiratory resistance is independent of traction bronchiectasis and airflow obstruction in patients with IPF, which implies that respiratory resistance might reflect different properties of the airways. |
format | Online Article Text |
id | pubmed-7737428 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | European Respiratory Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-77374282020-12-17 Oscillometry and computed tomography findings in patients with idiopathic pulmonary fibrosis Yamamoto, Yuji Miki, Keisuke Tsujino, Kazuyuki Kuge, Tomoki Okabe, Fukuko Kawasaki, Takahiro Matsuki, Takanori Kagawa, Hiroyuki Miki, Mari Kida, Hiroshi ERJ Open Res Original Articles Although the utility of oscillometry for predicting disease severity in idiopathic pulmonary fibrosis (IPF) had been researched, little has been reported on the mechanism of why respiratory impedance reflects disease severity. In addition, traction bronchiectasis has been considered to reduce respiratory resistance and correlate negatively with airflow obstruction, but this hypothesis has not been validated. The present study aimed to investigate the correlations between oscillometric parameters and fibrosis-related lung abnormalities in IPF and to assess the utility of oscillometry as a surrogate marker for traction bronchiectasis and airflow obstruction. Eighty Japanese patients with IPF underwent high-resolution computed tomography (HRCT), spirometry, and oscillometry and were retrospectively investigated. Fibrosis-related HRCT findings were scored regarding airspace consolidation, honeycombing, architectural distortion, traction bronchiectasis, and fibrosis. Correlations between the HRCT scores, spirometric parameters, and oscillometric parameters were analysed. Respiratory reactance correlated positively with all fibrosis-related HRCT scores. Vital capacity and forced vital capacity (FVC) correlated negatively with oscillometric parameters and HRCT scores, reflecting the severity of restrictive ventilatory deficiency. Respiratory resistance was not related to any of the HRCT scores or forced expiratory volume in 1 s/FVC. However, forced expiratory volume in 1 s/FVC correlated positively with HRCT scores, which showed that airflow obstruction became milder as the disease progressed. In conclusion, respiratory reactance reflects fibrosis and restrictive ventilatory deficiency in IPF. Moreover, respiratory resistance is independent of traction bronchiectasis and airflow obstruction in patients with IPF, which implies that respiratory resistance might reflect different properties of the airways. European Respiratory Society 2020-12-14 /pmc/articles/PMC7737428/ /pubmed/33344627 http://dx.doi.org/10.1183/23120541.00391-2020 Text en Copyright ©ERS 2020 http://creativecommons.org/licenses/by-nc/4.0/This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. |
spellingShingle | Original Articles Yamamoto, Yuji Miki, Keisuke Tsujino, Kazuyuki Kuge, Tomoki Okabe, Fukuko Kawasaki, Takahiro Matsuki, Takanori Kagawa, Hiroyuki Miki, Mari Kida, Hiroshi Oscillometry and computed tomography findings in patients with idiopathic pulmonary fibrosis |
title | Oscillometry and computed tomography findings in patients with idiopathic pulmonary fibrosis |
title_full | Oscillometry and computed tomography findings in patients with idiopathic pulmonary fibrosis |
title_fullStr | Oscillometry and computed tomography findings in patients with idiopathic pulmonary fibrosis |
title_full_unstemmed | Oscillometry and computed tomography findings in patients with idiopathic pulmonary fibrosis |
title_short | Oscillometry and computed tomography findings in patients with idiopathic pulmonary fibrosis |
title_sort | oscillometry and computed tomography findings in patients with idiopathic pulmonary fibrosis |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737428/ https://www.ncbi.nlm.nih.gov/pubmed/33344627 http://dx.doi.org/10.1183/23120541.00391-2020 |
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