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Oscillometry and computed tomography findings in patients with idiopathic pulmonary fibrosis

Although the utility of oscillometry for predicting disease severity in idiopathic pulmonary fibrosis (IPF) had been researched, little has been reported on the mechanism of why respiratory impedance reflects disease severity. In addition, traction bronchiectasis has been considered to reduce respir...

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Autores principales: Yamamoto, Yuji, Miki, Keisuke, Tsujino, Kazuyuki, Kuge, Tomoki, Okabe, Fukuko, Kawasaki, Takahiro, Matsuki, Takanori, Kagawa, Hiroyuki, Miki, Mari, Kida, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737428/
https://www.ncbi.nlm.nih.gov/pubmed/33344627
http://dx.doi.org/10.1183/23120541.00391-2020
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author Yamamoto, Yuji
Miki, Keisuke
Tsujino, Kazuyuki
Kuge, Tomoki
Okabe, Fukuko
Kawasaki, Takahiro
Matsuki, Takanori
Kagawa, Hiroyuki
Miki, Mari
Kida, Hiroshi
author_facet Yamamoto, Yuji
Miki, Keisuke
Tsujino, Kazuyuki
Kuge, Tomoki
Okabe, Fukuko
Kawasaki, Takahiro
Matsuki, Takanori
Kagawa, Hiroyuki
Miki, Mari
Kida, Hiroshi
author_sort Yamamoto, Yuji
collection PubMed
description Although the utility of oscillometry for predicting disease severity in idiopathic pulmonary fibrosis (IPF) had been researched, little has been reported on the mechanism of why respiratory impedance reflects disease severity. In addition, traction bronchiectasis has been considered to reduce respiratory resistance and correlate negatively with airflow obstruction, but this hypothesis has not been validated. The present study aimed to investigate the correlations between oscillometric parameters and fibrosis-related lung abnormalities in IPF and to assess the utility of oscillometry as a surrogate marker for traction bronchiectasis and airflow obstruction. Eighty Japanese patients with IPF underwent high-resolution computed tomography (HRCT), spirometry, and oscillometry and were retrospectively investigated. Fibrosis-related HRCT findings were scored regarding airspace consolidation, honeycombing, architectural distortion, traction bronchiectasis, and fibrosis. Correlations between the HRCT scores, spirometric parameters, and oscillometric parameters were analysed. Respiratory reactance correlated positively with all fibrosis-related HRCT scores. Vital capacity and forced vital capacity (FVC) correlated negatively with oscillometric parameters and HRCT scores, reflecting the severity of restrictive ventilatory deficiency. Respiratory resistance was not related to any of the HRCT scores or forced expiratory volume in 1 s/FVC. However, forced expiratory volume in 1 s/FVC correlated positively with HRCT scores, which showed that airflow obstruction became milder as the disease progressed. In conclusion, respiratory reactance reflects fibrosis and restrictive ventilatory deficiency in IPF. Moreover, respiratory resistance is independent of traction bronchiectasis and airflow obstruction in patients with IPF, which implies that respiratory resistance might reflect different properties of the airways.
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spelling pubmed-77374282020-12-17 Oscillometry and computed tomography findings in patients with idiopathic pulmonary fibrosis Yamamoto, Yuji Miki, Keisuke Tsujino, Kazuyuki Kuge, Tomoki Okabe, Fukuko Kawasaki, Takahiro Matsuki, Takanori Kagawa, Hiroyuki Miki, Mari Kida, Hiroshi ERJ Open Res Original Articles Although the utility of oscillometry for predicting disease severity in idiopathic pulmonary fibrosis (IPF) had been researched, little has been reported on the mechanism of why respiratory impedance reflects disease severity. In addition, traction bronchiectasis has been considered to reduce respiratory resistance and correlate negatively with airflow obstruction, but this hypothesis has not been validated. The present study aimed to investigate the correlations between oscillometric parameters and fibrosis-related lung abnormalities in IPF and to assess the utility of oscillometry as a surrogate marker for traction bronchiectasis and airflow obstruction. Eighty Japanese patients with IPF underwent high-resolution computed tomography (HRCT), spirometry, and oscillometry and were retrospectively investigated. Fibrosis-related HRCT findings were scored regarding airspace consolidation, honeycombing, architectural distortion, traction bronchiectasis, and fibrosis. Correlations between the HRCT scores, spirometric parameters, and oscillometric parameters were analysed. Respiratory reactance correlated positively with all fibrosis-related HRCT scores. Vital capacity and forced vital capacity (FVC) correlated negatively with oscillometric parameters and HRCT scores, reflecting the severity of restrictive ventilatory deficiency. Respiratory resistance was not related to any of the HRCT scores or forced expiratory volume in 1 s/FVC. However, forced expiratory volume in 1 s/FVC correlated positively with HRCT scores, which showed that airflow obstruction became milder as the disease progressed. In conclusion, respiratory reactance reflects fibrosis and restrictive ventilatory deficiency in IPF. Moreover, respiratory resistance is independent of traction bronchiectasis and airflow obstruction in patients with IPF, which implies that respiratory resistance might reflect different properties of the airways. European Respiratory Society 2020-12-14 /pmc/articles/PMC7737428/ /pubmed/33344627 http://dx.doi.org/10.1183/23120541.00391-2020 Text en Copyright ©ERS 2020 http://creativecommons.org/licenses/by-nc/4.0/This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.
spellingShingle Original Articles
Yamamoto, Yuji
Miki, Keisuke
Tsujino, Kazuyuki
Kuge, Tomoki
Okabe, Fukuko
Kawasaki, Takahiro
Matsuki, Takanori
Kagawa, Hiroyuki
Miki, Mari
Kida, Hiroshi
Oscillometry and computed tomography findings in patients with idiopathic pulmonary fibrosis
title Oscillometry and computed tomography findings in patients with idiopathic pulmonary fibrosis
title_full Oscillometry and computed tomography findings in patients with idiopathic pulmonary fibrosis
title_fullStr Oscillometry and computed tomography findings in patients with idiopathic pulmonary fibrosis
title_full_unstemmed Oscillometry and computed tomography findings in patients with idiopathic pulmonary fibrosis
title_short Oscillometry and computed tomography findings in patients with idiopathic pulmonary fibrosis
title_sort oscillometry and computed tomography findings in patients with idiopathic pulmonary fibrosis
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737428/
https://www.ncbi.nlm.nih.gov/pubmed/33344627
http://dx.doi.org/10.1183/23120541.00391-2020
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