Hepcidin Is a Reliable Marker of Iron Deficiency Anemia in Newly Diagnosed Patients with Inflammatory Bowel Disease

RESULTS: There was a high statistically significant difference between IBD patients and controls in levels of hepcidin (P < 0.01). Namely, serum hepcidin levels were significantly higher in the control group. There was no statistically significant correlation of serum hepcidin with CRP, Mayo scor...

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Autores principales: Stojkovic Lalosevic, Milica, Toncev, Ljubisa, Stankovic, Sanja, Dragasevic, Sanja, Stojkovic, Stefan, Jovicic, Ivana, Stulic, Milos, Culafic, Djordje, Milovanovic, Tamara, Stojanovic, Marija, Aleksic, Marko, Stjepanovic, Mihailo, Lalosevic, Jovan, Kiurski, Stanimir, Oluic, Branislav, Pavlovic Markovic, Aleksandra, Stojkovic, Mirjana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737436/
https://www.ncbi.nlm.nih.gov/pubmed/33354248
http://dx.doi.org/10.1155/2020/8523205
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author Stojkovic Lalosevic, Milica
Toncev, Ljubisa
Stankovic, Sanja
Dragasevic, Sanja
Stojkovic, Stefan
Jovicic, Ivana
Stulic, Milos
Culafic, Djordje
Milovanovic, Tamara
Stojanovic, Marija
Aleksic, Marko
Stjepanovic, Mihailo
Lalosevic, Jovan
Kiurski, Stanimir
Oluic, Branislav
Pavlovic Markovic, Aleksandra
Stojkovic, Mirjana
author_facet Stojkovic Lalosevic, Milica
Toncev, Ljubisa
Stankovic, Sanja
Dragasevic, Sanja
Stojkovic, Stefan
Jovicic, Ivana
Stulic, Milos
Culafic, Djordje
Milovanovic, Tamara
Stojanovic, Marija
Aleksic, Marko
Stjepanovic, Mihailo
Lalosevic, Jovan
Kiurski, Stanimir
Oluic, Branislav
Pavlovic Markovic, Aleksandra
Stojkovic, Mirjana
author_sort Stojkovic Lalosevic, Milica
collection PubMed
description RESULTS: There was a high statistically significant difference between IBD patients and controls in levels of hepcidin (P < 0.01). Namely, serum hepcidin levels were significantly higher in the control group. There was no statistically significant correlation of serum hepcidin with CRP, Mayo score, or CDAI, respectively (P > 0.05). However, we have found a statistically significant negative correlation of sTfR and TIBC with hepcidin (P < 0.01). CONCLUSION: Results of our study suggest that hepcidin is a reliable marker of IDA in patients with IBD, and it could be used in routine clinical practice when determining adequate therapy in these patients.
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spelling pubmed-77374362020-12-21 Hepcidin Is a Reliable Marker of Iron Deficiency Anemia in Newly Diagnosed Patients with Inflammatory Bowel Disease Stojkovic Lalosevic, Milica Toncev, Ljubisa Stankovic, Sanja Dragasevic, Sanja Stojkovic, Stefan Jovicic, Ivana Stulic, Milos Culafic, Djordje Milovanovic, Tamara Stojanovic, Marija Aleksic, Marko Stjepanovic, Mihailo Lalosevic, Jovan Kiurski, Stanimir Oluic, Branislav Pavlovic Markovic, Aleksandra Stojkovic, Mirjana Dis Markers Research Article RESULTS: There was a high statistically significant difference between IBD patients and controls in levels of hepcidin (P < 0.01). Namely, serum hepcidin levels were significantly higher in the control group. There was no statistically significant correlation of serum hepcidin with CRP, Mayo score, or CDAI, respectively (P > 0.05). However, we have found a statistically significant negative correlation of sTfR and TIBC with hepcidin (P < 0.01). CONCLUSION: Results of our study suggest that hepcidin is a reliable marker of IDA in patients with IBD, and it could be used in routine clinical practice when determining adequate therapy in these patients. Hindawi 2020-11-28 /pmc/articles/PMC7737436/ /pubmed/33354248 http://dx.doi.org/10.1155/2020/8523205 Text en Copyright © 2020 Milica Stojkovic Lalosevic et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Stojkovic Lalosevic, Milica
Toncev, Ljubisa
Stankovic, Sanja
Dragasevic, Sanja
Stojkovic, Stefan
Jovicic, Ivana
Stulic, Milos
Culafic, Djordje
Milovanovic, Tamara
Stojanovic, Marija
Aleksic, Marko
Stjepanovic, Mihailo
Lalosevic, Jovan
Kiurski, Stanimir
Oluic, Branislav
Pavlovic Markovic, Aleksandra
Stojkovic, Mirjana
Hepcidin Is a Reliable Marker of Iron Deficiency Anemia in Newly Diagnosed Patients with Inflammatory Bowel Disease
title Hepcidin Is a Reliable Marker of Iron Deficiency Anemia in Newly Diagnosed Patients with Inflammatory Bowel Disease
title_full Hepcidin Is a Reliable Marker of Iron Deficiency Anemia in Newly Diagnosed Patients with Inflammatory Bowel Disease
title_fullStr Hepcidin Is a Reliable Marker of Iron Deficiency Anemia in Newly Diagnosed Patients with Inflammatory Bowel Disease
title_full_unstemmed Hepcidin Is a Reliable Marker of Iron Deficiency Anemia in Newly Diagnosed Patients with Inflammatory Bowel Disease
title_short Hepcidin Is a Reliable Marker of Iron Deficiency Anemia in Newly Diagnosed Patients with Inflammatory Bowel Disease
title_sort hepcidin is a reliable marker of iron deficiency anemia in newly diagnosed patients with inflammatory bowel disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737436/
https://www.ncbi.nlm.nih.gov/pubmed/33354248
http://dx.doi.org/10.1155/2020/8523205
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