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Acute and Subchronic Oral Safety Profiles of the Sudarshana Suspension

Sudarshana powder (SP) is an Ayurvedic preparation, which contains 53 herbal ingredients along with 50% of Andrographis paniculata and is clinically used with bees honey. This study was aimed to determine the safety profile of the SP, and its novel preparation Sudarshana suspension (SS) on male Wist...

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Autores principales: Weerakoon, Weerakoon Achchige Selvi Saroja, Perera, Pathirage Kamal, Samarasinghe, Kamani, Gunasekera, Dulani, Suresh, Thusharie Sugandhika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737453/
https://www.ncbi.nlm.nih.gov/pubmed/33354219
http://dx.doi.org/10.1155/2020/2891058
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author Weerakoon, Weerakoon Achchige Selvi Saroja
Perera, Pathirage Kamal
Samarasinghe, Kamani
Gunasekera, Dulani
Suresh, Thusharie Sugandhika
author_facet Weerakoon, Weerakoon Achchige Selvi Saroja
Perera, Pathirage Kamal
Samarasinghe, Kamani
Gunasekera, Dulani
Suresh, Thusharie Sugandhika
author_sort Weerakoon, Weerakoon Achchige Selvi Saroja
collection PubMed
description Sudarshana powder (SP) is an Ayurvedic preparation, which contains 53 herbal ingredients along with 50% of Andrographis paniculata and is clinically used with bees honey. This study was aimed to determine the safety profile of the SP, and its novel preparation Sudarshana suspension (SS) on male Wistar rats and tolerance studies were conducted for healthy adult volunteers. Acute and subacute toxicity studies of the SS and hot water extract of SP were assessed in Wistar rats by observing the general behavior, analyzing biochemical and haematological parameters, and pathological observation. Healthy consented adult volunteers (n = 35) of either sex were selected, and tolerance studies of SS were tested by measuring the biochemical and haematological parameters. There were no significant (p > 0.05) changes observed in the treated animals with SS and hot water extract of SP compared with control in body weights, food intake, and water consumption as well as the biochemical and haematological parameters. Histopathological studies revealed no significant (p > 0.05) changes in the liver, heart, and kidney tissues. The experimental results suggest that novel formulation SS was potentially safe for chronic administration in rats, and no significant differences (p > 0.05) were observed in tested parameters on day 3 and day 8 when compared to the day 0 (baseline) values in healthy volunteers. Healthy volunteers did not report any adverse effects or any other complications during the treatment period and the follow-up period. Therefore, it can be concluded that the novel preparation Sudarshana suspension does not cause any significant toxic effects on the blood parameters in animal and human models.
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spelling pubmed-77374532020-12-21 Acute and Subchronic Oral Safety Profiles of the Sudarshana Suspension Weerakoon, Weerakoon Achchige Selvi Saroja Perera, Pathirage Kamal Samarasinghe, Kamani Gunasekera, Dulani Suresh, Thusharie Sugandhika Evid Based Complement Alternat Med Research Article Sudarshana powder (SP) is an Ayurvedic preparation, which contains 53 herbal ingredients along with 50% of Andrographis paniculata and is clinically used with bees honey. This study was aimed to determine the safety profile of the SP, and its novel preparation Sudarshana suspension (SS) on male Wistar rats and tolerance studies were conducted for healthy adult volunteers. Acute and subacute toxicity studies of the SS and hot water extract of SP were assessed in Wistar rats by observing the general behavior, analyzing biochemical and haematological parameters, and pathological observation. Healthy consented adult volunteers (n = 35) of either sex were selected, and tolerance studies of SS were tested by measuring the biochemical and haematological parameters. There were no significant (p > 0.05) changes observed in the treated animals with SS and hot water extract of SP compared with control in body weights, food intake, and water consumption as well as the biochemical and haematological parameters. Histopathological studies revealed no significant (p > 0.05) changes in the liver, heart, and kidney tissues. The experimental results suggest that novel formulation SS was potentially safe for chronic administration in rats, and no significant differences (p > 0.05) were observed in tested parameters on day 3 and day 8 when compared to the day 0 (baseline) values in healthy volunteers. Healthy volunteers did not report any adverse effects or any other complications during the treatment period and the follow-up period. Therefore, it can be concluded that the novel preparation Sudarshana suspension does not cause any significant toxic effects on the blood parameters in animal and human models. Hindawi 2020-11-28 /pmc/articles/PMC7737453/ /pubmed/33354219 http://dx.doi.org/10.1155/2020/2891058 Text en Copyright © 2020 Weerakoon Achchige Selvi Saroja Weerakoon et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Weerakoon, Weerakoon Achchige Selvi Saroja
Perera, Pathirage Kamal
Samarasinghe, Kamani
Gunasekera, Dulani
Suresh, Thusharie Sugandhika
Acute and Subchronic Oral Safety Profiles of the Sudarshana Suspension
title Acute and Subchronic Oral Safety Profiles of the Sudarshana Suspension
title_full Acute and Subchronic Oral Safety Profiles of the Sudarshana Suspension
title_fullStr Acute and Subchronic Oral Safety Profiles of the Sudarshana Suspension
title_full_unstemmed Acute and Subchronic Oral Safety Profiles of the Sudarshana Suspension
title_short Acute and Subchronic Oral Safety Profiles of the Sudarshana Suspension
title_sort acute and subchronic oral safety profiles of the sudarshana suspension
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737453/
https://www.ncbi.nlm.nih.gov/pubmed/33354219
http://dx.doi.org/10.1155/2020/2891058
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