Cargando…

Bioinformatics prediction of B and T cell epitopes within the spike and nucleocapsid proteins of SARS-CoV2

BACKGROUND: The striking difference in severity of SARS CoV2 infection among global population is partly attributed to viral factors. With the spike (S) and nucleocapsid (N) are the most immunogenic subunits, genetic diversity and antigenicity of S and N are key players in virulence and in vaccine d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dawood, Reham M., El-Meguid, Mai A., Salum, Ghada M., El-Wakeel, Khaled, Shemis, Mohamed, El Awady, Mostafa K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Authors. Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences. 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737509/ https://www.ncbi.nlm.nih.gov/pubmed/33486372 http://dx.doi.org/10.1016/j.jiph.2020.12.006

Ejemplares similares

Bioinformatics analysis of multi-epitope peptide vaccines against Hepatitis C virus: a molecular docking study
por: Muhammad, Ashraf M., et al.
Publicado: (2023)

Correlation between IL28B/TLR4 genetic variants and HCC development with/without DAAs treatment in chronic HCV patients
por: Salum, Ghada M., et al.
Publicado: (2019)

The Impact of COVID-19 on Liver Injury
por: Dawood, Dr. Reham M., et al.
Publicado: (2022)

The Impact of Direct-Acting Antiviral Agents on Cytomegalovirus Reactivation in Chronic Hepatitis C Infection
por: Dawood, Reham M, et al.
Publicado: (2022)

Significance of Hereditary Hemochromatosis Gene (HFE) Mutations in Chronic Hepatitis C and Hepatocellular Carcinoma Patients in Egypt: A Pilot Study
por: Dawood, Reham M, et al.
Publicado: (2021)

Evaluation of seven gene signature for predicting HCV recurrence post-liver transplantation
por: Salum, Ghada M., et al.
Publicado: (2021)

Transcriptional Dysregulation of Upstream Signaling of IFN Pathway in Chronic HCV Type 4 Induced Liver Fibrosis
por: Ibrahim, Marwa K., et al.
Publicado: (2016)

Seven gene signature explores the impact of DAAs on the appearance of hepatocellular carcinoma in HCV infected patients
por: Dawood, Reham M., et al.
Publicado: (2022)

Polymorphism in Variable Number of Tandem Repeats of Dopamine D4 Gene Is a Genetic Risk Factor in Attention Deficit Hyperactive Egyptian Children: Pilot Study
por: Shahin, Ola, et al.
Publicado: (2015)

HCV treatment outcome depends on SNPs of IFNL3-Gene polymorphisms (rs12979860) and cirrhotic changes in liver parenchyma
por: Abd Alla, Mohamed Darwish Ahmed, et al.
Publicado: (2023)

Identification of Conserved Epitopes in SARS-CoV-2 Spike and Nucleocapsid Protein
por: Forcelloni, Sergio, et al.
Publicado: (2021)

Expression of Reactive Oxygen Species–Related Transcripts in Egyptian Children With Autism
por: Meguid, Nagwa A, et al.
Publicado: (2017)

Identification of SARS-CoV-2 Nucleocapsid and Spike T-Cell Epitopes for Assessing T-Cell Immunity
por: Lee, Eunok, et al.
Publicado: (2021)

Detection of Occult Hepatitis C Virus Infection in Egyptian Patients Who Achieved a Sustained Virologic Response to Direct-Acting Antiviral Agents
por: Mashaal, Ahmed R, et al.
Publicado: (2022)

Heterogeneity and New Epitopes of Hepatitis C Virus Genotype 4
por: Omran, Moataza H., et al.
Publicado: (2013)

MTHFR Genetic Polymorphism As a Risk Factor in Egyptian Mothers with Down Syndrome Children
por: Meguid, Nagwa A., et al.
Publicado: (2008)

Recognition of 7 genes signature (Cirrhosis Risk Score) in the diagnosed non-responders to DAAs therapy by intra-PBMCs nested HCV RNA PCR
por: Galal, Al-Shazly Gaber Mohamed, et al.
Publicado: (2023)

The Epitope Study on the SARS-CoV Nucleocapsid Protein
por: Li, Shuting, et al.
Publicado: (2003)

Linear B-cell epitopes in the spike and nucleocapsid proteins as markers of SARS-CoV-2 exposure and disease severity
por: Amrun, Siti Naqiah, et al.
Publicado: (2020)

HCV Therapy Follow-up Fractionation (CTF2) by Intra-PBMC Nested RNA PCR Recognizes Early Virologic Response and Relapse
por: Abd Alla, Mohamed Darwish Ahmed, et al.
Publicado: (2018)

A multiepitope peptide vaccine against HCV stimulates neutralizing humoral and persistent cellular responses in mice
por: Dawood, Reham M., et al.
Publicado: (2019)

Screening of Dystrophin Gene Deletions in Egyptian Patients with DMD/BMD Muscular Dystrophies
por: Effat, Laila K., et al.
Publicado: (2000)

HLA-A(∗)0201 T-cell epitopes in severe acute respiratory syndrome (SARS) coronavirus nucleocapsid and spike proteins
por: Tsao, Yeou-Ping, et al.
Publicado: (2006)

Human CD4(+) T cells specific for dominant epitopes of SARS‐CoV‐2 Spike and Nucleocapsid proteins with therapeutic potential
por: Verhagen, Johan, et al.
Publicado: (2021)

State of the art in epitope mapping and opportunities in COVID-19
por: Hamed, Samira M, et al.
Publicado: (2023)

Bioinformatics-based SARS-CoV-2 epitopes design and the impact of spike protein mutants on epitope humoral immunities
por: Sun, Qi, et al.
Publicado: (2022)

Identification of an epitope of SARS-coronavirus nucleocapsid protein
por: LIN, Ying, et al.
Publicado: (2003)

Tumor necrosis factor-α -G308A polymorphism is associated with liver pathological changes in hepatitis C virus patients
por: Bader El Din, Noha G, et al.
Publicado: (2016)

Antibody detection of SARS-CoV spike and nucleocapsid protein
por: Chang, Mau-Sun, et al.
Publicado: (2004)

In-silico design of a multi-epitope for developing sero-diagnosis detection of SARS-CoV-2 using spike glycoprotein and nucleocapsid antigens
por: Javadi Mamaghani, Amirreza, et al.
Publicado: (2021)

Cytotoxic T lymphocytes recognize an HLA-A2-restricted epitope within the hepatitis B virus nucleocapsid antigen
Publicado: (1991)

A Study of CC-Chemokine Receptor 5 (CCR5) Polymorphism on the Outcome of HCV Therapy in Egyptian Patients
por: Omran, Moataza H, et al.
Publicado: (2013)

Performance of nucleocapsid and spike-based SARS-CoV-2 serologic assays
por: Rikhtegaran Tehrani, Zahra, et al.
Publicado: (2020)

Conserved peptides within the E2 region of Hepatitis C virus induce humoral and cellular responses in goats
por: El-Awady, Mostafa K, et al.
Publicado: (2009)

Screening and identification of T helper 1 and linear immunodominant antibody-binding epitopes in the spike 2 domain and the nucleocapsid protein of feline infectious peritonitis virus
por: Satoh, Ryoichi, et al.
Publicado: (2011)

A Bioinformatics Evaluation of the Role of Dual-Specificity Tyrosine-Regulated Kinases in Colorectal Cancer
por: Laham, Amina Jamal, et al.
Publicado: (2022)

Exploring the Immunodominant Epitopes of SARS-CoV-2 Nucleocapsid Protein as Exposure Biomarker
por: Vashisht, Kapil, et al.
Publicado: (2023)

Specificity and Performance of Nucleocapsid and Spike-based SARS-CoV-2 Serologic Assays
por: Tehrani, Zahra Rikhtegaran, et al.
Publicado: (2020)

Search for potential target site of nucleocapsid gene for the design of an epitope-based SARS DNA vaccine
por: Dutta, Noton Kumar, et al.
Publicado: (2008)

Hepatitis C Virus RNA Strands Detection in Peripheral Blood Mononuclear Cells Legitimizes Virus Eradication in Negative Serum PCR Naïve and Post-treatment Patients
por: Abd Alla, Mohamed Darwish Ahmed, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ok4mlcmrcub4n37ti0gc1ofv37