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Distinct Dengue Disease Epidemiology, Clinical, and Diagnosis Features in Western, Central, and Eastern Regions of Indonesia, 2017–2019

The people of Indonesia have been afflicted by dengue, a mosquito-borne viral disease, for over 5 decades. The country is the world's largest archipelago with diverse geographic, climatic, and demographic conditions that may impact the dynamics of disease transmissions. A dengue epidemiology st...

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Autores principales: Sasmono, R. Tedjo, Santoso, Marsha S., Pamai, Yanuarni W. B., Yohan, Benediktus, Afida, Anna M., Denis, Dionisius, Hutagalung, Ingrid A., Johar, Edison, Hayati, Rahma F., Yudhaputri, Frilasita A., Haryanto, Sotianingsih, Stubbs, Samuel C. B., Blacklaws, Barbara A., Myint, Khin S. A., Frost, Simon D. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737558/
https://www.ncbi.nlm.nih.gov/pubmed/33335904
http://dx.doi.org/10.3389/fmed.2020.582235
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author Sasmono, R. Tedjo
Santoso, Marsha S.
Pamai, Yanuarni W. B.
Yohan, Benediktus
Afida, Anna M.
Denis, Dionisius
Hutagalung, Ingrid A.
Johar, Edison
Hayati, Rahma F.
Yudhaputri, Frilasita A.
Haryanto, Sotianingsih
Stubbs, Samuel C. B.
Blacklaws, Barbara A.
Myint, Khin S. A.
Frost, Simon D. W.
author_facet Sasmono, R. Tedjo
Santoso, Marsha S.
Pamai, Yanuarni W. B.
Yohan, Benediktus
Afida, Anna M.
Denis, Dionisius
Hutagalung, Ingrid A.
Johar, Edison
Hayati, Rahma F.
Yudhaputri, Frilasita A.
Haryanto, Sotianingsih
Stubbs, Samuel C. B.
Blacklaws, Barbara A.
Myint, Khin S. A.
Frost, Simon D. W.
author_sort Sasmono, R. Tedjo
collection PubMed
description The people of Indonesia have been afflicted by dengue, a mosquito-borne viral disease, for over 5 decades. The country is the world's largest archipelago with diverse geographic, climatic, and demographic conditions that may impact the dynamics of disease transmissions. A dengue epidemiology study was launched by us to compare and understand the dynamics of dengue and other arboviral diseases in three cities representing western, central, and eastern Indonesia, namely, Batam, Banjarmasin, and Ambon, respectively. A total of 732 febrile patients were recruited with dengue-like illness during September 2017–2019 and an analysis of their demographic, clinical, and virological features was performed. The seasonal patterns of dengue-like illness were found to be different in the three regions. Among all patients, 271 (37.0%) were virologically confirmed dengue, while 152 (20.8%) patients were diagnosed with probable dengue, giving a total number of 423 (57.8%) dengue patients. Patients' age and clinical manifestations also differed between cities. Mostly, mild dengue fever was observed in Batam, while more severe cases were prominent in Ambon. While all dengue virus (DENV) serotypes were detected, distinct serotypes dominated in different locations: DENV-1 in Batam and Ambon, and DENV-3 in Banjarmasin. We also assessed the diagnostic features in the study sites, which revealed different patterns of diagnostic agreements, particularly in Ambon. To detect the possibility of infection with other arboviruses, further testing on 461 DENV RT-PCR-negative samples was performed using pan-flavivirus and -alphavirus RT-PCRs; however, only one chikungunya infection was detected in Ambon. A diverse dengue epidemiology in western, central, and eastern Indonesia was observed, which is likely to be influenced by local geographic, climatic, and demographic conditions, as well as differences in the quality of healthcare providers and facilities. Our study adds a new understanding on dengue epidemiology in Indonesia.
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spelling pubmed-77375582020-12-16 Distinct Dengue Disease Epidemiology, Clinical, and Diagnosis Features in Western, Central, and Eastern Regions of Indonesia, 2017–2019 Sasmono, R. Tedjo Santoso, Marsha S. Pamai, Yanuarni W. B. Yohan, Benediktus Afida, Anna M. Denis, Dionisius Hutagalung, Ingrid A. Johar, Edison Hayati, Rahma F. Yudhaputri, Frilasita A. Haryanto, Sotianingsih Stubbs, Samuel C. B. Blacklaws, Barbara A. Myint, Khin S. A. Frost, Simon D. W. Front Med (Lausanne) Medicine The people of Indonesia have been afflicted by dengue, a mosquito-borne viral disease, for over 5 decades. The country is the world's largest archipelago with diverse geographic, climatic, and demographic conditions that may impact the dynamics of disease transmissions. A dengue epidemiology study was launched by us to compare and understand the dynamics of dengue and other arboviral diseases in three cities representing western, central, and eastern Indonesia, namely, Batam, Banjarmasin, and Ambon, respectively. A total of 732 febrile patients were recruited with dengue-like illness during September 2017–2019 and an analysis of their demographic, clinical, and virological features was performed. The seasonal patterns of dengue-like illness were found to be different in the three regions. Among all patients, 271 (37.0%) were virologically confirmed dengue, while 152 (20.8%) patients were diagnosed with probable dengue, giving a total number of 423 (57.8%) dengue patients. Patients' age and clinical manifestations also differed between cities. Mostly, mild dengue fever was observed in Batam, while more severe cases were prominent in Ambon. While all dengue virus (DENV) serotypes were detected, distinct serotypes dominated in different locations: DENV-1 in Batam and Ambon, and DENV-3 in Banjarmasin. We also assessed the diagnostic features in the study sites, which revealed different patterns of diagnostic agreements, particularly in Ambon. To detect the possibility of infection with other arboviruses, further testing on 461 DENV RT-PCR-negative samples was performed using pan-flavivirus and -alphavirus RT-PCRs; however, only one chikungunya infection was detected in Ambon. A diverse dengue epidemiology in western, central, and eastern Indonesia was observed, which is likely to be influenced by local geographic, climatic, and demographic conditions, as well as differences in the quality of healthcare providers and facilities. Our study adds a new understanding on dengue epidemiology in Indonesia. Frontiers Media S.A. 2020-11-20 /pmc/articles/PMC7737558/ /pubmed/33335904 http://dx.doi.org/10.3389/fmed.2020.582235 Text en Copyright © 2020 Sasmono, Santoso, Pamai, Yohan, Afida, Denis, Hutagalung, Johar, Hayati, Yudhaputri, Haryanto, Stubbs, Blacklaws, Myint and Frost. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Sasmono, R. Tedjo
Santoso, Marsha S.
Pamai, Yanuarni W. B.
Yohan, Benediktus
Afida, Anna M.
Denis, Dionisius
Hutagalung, Ingrid A.
Johar, Edison
Hayati, Rahma F.
Yudhaputri, Frilasita A.
Haryanto, Sotianingsih
Stubbs, Samuel C. B.
Blacklaws, Barbara A.
Myint, Khin S. A.
Frost, Simon D. W.
Distinct Dengue Disease Epidemiology, Clinical, and Diagnosis Features in Western, Central, and Eastern Regions of Indonesia, 2017–2019
title Distinct Dengue Disease Epidemiology, Clinical, and Diagnosis Features in Western, Central, and Eastern Regions of Indonesia, 2017–2019
title_full Distinct Dengue Disease Epidemiology, Clinical, and Diagnosis Features in Western, Central, and Eastern Regions of Indonesia, 2017–2019
title_fullStr Distinct Dengue Disease Epidemiology, Clinical, and Diagnosis Features in Western, Central, and Eastern Regions of Indonesia, 2017–2019
title_full_unstemmed Distinct Dengue Disease Epidemiology, Clinical, and Diagnosis Features in Western, Central, and Eastern Regions of Indonesia, 2017–2019
title_short Distinct Dengue Disease Epidemiology, Clinical, and Diagnosis Features in Western, Central, and Eastern Regions of Indonesia, 2017–2019
title_sort distinct dengue disease epidemiology, clinical, and diagnosis features in western, central, and eastern regions of indonesia, 2017–2019
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737558/
https://www.ncbi.nlm.nih.gov/pubmed/33335904
http://dx.doi.org/10.3389/fmed.2020.582235
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