Hemophagocytic Lymphohistiocytosis in Langerhans Cell Histiocytosis: A Case Report and Review of the Literature

A toddler undergoing treatment for refractory Langerhans cell histiocytosis (LCH) developed concurrent hemophagocytic lymphohistiocytosis (HLH). These are thought to be distinct histiocytic disorders, with different pathophysiologies, diagnostic criteria, and treatments. HLH in a patient with LCH is...

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Detalles Bibliográficos
Autores principales: Hinson, Ashley R.P., Patel, Niraj, Kaplan, Joel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Clinical and Laboratory Observations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737855/
https://www.ncbi.nlm.nih.gov/pubmed/31725543
http://dx.doi.org/10.1097/MPH.0000000000001652
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author Hinson, Ashley R.P.
Patel, Niraj
Kaplan, Joel
author_facet Hinson, Ashley R.P.
Patel, Niraj
Kaplan, Joel
author_sort Hinson, Ashley R.P.
collection PubMed
description A toddler undergoing treatment for refractory Langerhans cell histiocytosis (LCH) developed concurrent hemophagocytic lymphohistiocytosis (HLH). These are thought to be distinct histiocytic disorders, with different pathophysiologies, diagnostic criteria, and treatments. HLH in a patient with LCH is thought to be quite rare. In this report, we review the presentation of our patient, as well as review the existing literature of other pediatric patients who have been diagnosed with both LCH and HLH.
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spelling pubmed-77378552020-12-22 Hemophagocytic Lymphohistiocytosis in Langerhans Cell Histiocytosis: A Case Report and Review of the Literature Hinson, Ashley R.P. Patel, Niraj Kaplan, Joel J Pediatr Hematol Oncol Clinical and Laboratory Observations A toddler undergoing treatment for refractory Langerhans cell histiocytosis (LCH) developed concurrent hemophagocytic lymphohistiocytosis (HLH). These are thought to be distinct histiocytic disorders, with different pathophysiologies, diagnostic criteria, and treatments. HLH in a patient with LCH is thought to be quite rare. In this report, we review the presentation of our patient, as well as review the existing literature of other pediatric patients who have been diagnosed with both LCH and HLH. Lippincott Williams & Wilkins 2021-01 2019-11-12 /pmc/articles/PMC7737855/ /pubmed/31725543 http://dx.doi.org/10.1097/MPH.0000000000001652 Text en Copyright © 2019 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Clinical and Laboratory Observations
Hinson, Ashley R.P.
Patel, Niraj
Kaplan, Joel
Hemophagocytic Lymphohistiocytosis in Langerhans Cell Histiocytosis: A Case Report and Review of the Literature
title Hemophagocytic Lymphohistiocytosis in Langerhans Cell Histiocytosis: A Case Report and Review of the Literature
title_full Hemophagocytic Lymphohistiocytosis in Langerhans Cell Histiocytosis: A Case Report and Review of the Literature
title_fullStr Hemophagocytic Lymphohistiocytosis in Langerhans Cell Histiocytosis: A Case Report and Review of the Literature
title_full_unstemmed Hemophagocytic Lymphohistiocytosis in Langerhans Cell Histiocytosis: A Case Report and Review of the Literature
title_short Hemophagocytic Lymphohistiocytosis in Langerhans Cell Histiocytosis: A Case Report and Review of the Literature
title_sort hemophagocytic lymphohistiocytosis in langerhans cell histiocytosis: a case report and review of the literature
topic Clinical and Laboratory Observations
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737855/
https://www.ncbi.nlm.nih.gov/pubmed/31725543
http://dx.doi.org/10.1097/MPH.0000000000001652
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AT kaplanjoel hemophagocyticlymphohistiocytosisinlangerhanscellhistiocytosisacasereportandreviewoftheliterature

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