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Serum Acylglycerols Inversely Associate with Muscle Oxidative Capacity in Severe COPD
PURPOSE: Chronic obstructive pulmonary disease (COPD) is associated with altered metabolism and body composition that accompany poor outcomes. We aimed to determine whether metabolic derangements in COPD are associated with skeletal muscle deconditioning and/or physical inactivity, independent of pu...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737871/ https://www.ncbi.nlm.nih.gov/pubmed/32694368 http://dx.doi.org/10.1249/MSS.0000000000002441 |
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author | LI, RONGSONG ADAMI, ALESSANDRA CHANG, CHIH-CHIANG TSENG, CHI-HONG HSIAI, TZUNG K. ROSSITER, HARRY B. |
author_facet | LI, RONGSONG ADAMI, ALESSANDRA CHANG, CHIH-CHIANG TSENG, CHI-HONG HSIAI, TZUNG K. ROSSITER, HARRY B. |
author_sort | LI, RONGSONG |
collection | PubMed |
description | PURPOSE: Chronic obstructive pulmonary disease (COPD) is associated with altered metabolism and body composition that accompany poor outcomes. We aimed to determine whether metabolic derangements in COPD are associated with skeletal muscle deconditioning and/or physical inactivity, independent of pulmonary obstruction. METHODS: We characterized serum metabolites associated with muscle oxidative capacity or physical activity in 44 COPD patients (forced expiratory volume in 1 s [FEV(1)] = 61% ± 4% predicted) and 63 current and former smokers with normal spirometry (CON) (FEV(1) = 93% ± 2% predicted). Medial gastrocnemius oxidative capacity was assessed at rest from the recovery rate constant (k) of muscle oxygen consumption using near-infrared spectroscopy. Step counts and physical activity (average vector magnitude units [VMU] per minute) were measured over 5–7 d using triaxial accelerometry. Untargeted prime and lipid metabolites were measured using liquid chromatography and mass spectrometry. RESULTS: Muscle k (1.12 ± 0.05 vs 1.68 ± 0.06 min(−1), P < 0.0001, d = 1.58) and VMU per minute (170 ± 26 vs 450 ± 50 VMU per minute, P = 0.004, d = 1.04) were lower in severe COPD (FEV(1) < 50% predicted, n = 14–16) compared with CON (n = 56–60). A total of 129 prime metabolites and 470 lipids with known identity were quantified. Using sex as a covariate, lipidomics revealed 24 differentially expressed lipids (19 sphingomyelins) in COPD, consequent to a diminished sex difference of sphingomyelins in COPD (false discovery rate [FDR] < 0.05, n = 44). Total, and some individual, fatty acid concentrations were greater in severe COPD than CON (FDR < 0.05, n = 16, d = 0.56–1.02). After adjusting for FEV(1)% predicted, we observed that grouped diacylglycerides (ρ = −0.745, FDR = 0.03) and triacylglycerides (ρ = −0.811, FDR = 0.01) were negatively associated with muscle oxidative capacity, but not physical activity, in severe COPD (n = 14). CONCLUSION: Strong negative associations relate impaired mitochondrial function to the accumulation of serum aclyglycerides in severe COPD. |
format | Online Article Text |
id | pubmed-7737871 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-77378712020-12-22 Serum Acylglycerols Inversely Associate with Muscle Oxidative Capacity in Severe COPD LI, RONGSONG ADAMI, ALESSANDRA CHANG, CHIH-CHIANG TSENG, CHI-HONG HSIAI, TZUNG K. ROSSITER, HARRY B. Med Sci Sports Exerc Clinical Sciences PURPOSE: Chronic obstructive pulmonary disease (COPD) is associated with altered metabolism and body composition that accompany poor outcomes. We aimed to determine whether metabolic derangements in COPD are associated with skeletal muscle deconditioning and/or physical inactivity, independent of pulmonary obstruction. METHODS: We characterized serum metabolites associated with muscle oxidative capacity or physical activity in 44 COPD patients (forced expiratory volume in 1 s [FEV(1)] = 61% ± 4% predicted) and 63 current and former smokers with normal spirometry (CON) (FEV(1) = 93% ± 2% predicted). Medial gastrocnemius oxidative capacity was assessed at rest from the recovery rate constant (k) of muscle oxygen consumption using near-infrared spectroscopy. Step counts and physical activity (average vector magnitude units [VMU] per minute) were measured over 5–7 d using triaxial accelerometry. Untargeted prime and lipid metabolites were measured using liquid chromatography and mass spectrometry. RESULTS: Muscle k (1.12 ± 0.05 vs 1.68 ± 0.06 min(−1), P < 0.0001, d = 1.58) and VMU per minute (170 ± 26 vs 450 ± 50 VMU per minute, P = 0.004, d = 1.04) were lower in severe COPD (FEV(1) < 50% predicted, n = 14–16) compared with CON (n = 56–60). A total of 129 prime metabolites and 470 lipids with known identity were quantified. Using sex as a covariate, lipidomics revealed 24 differentially expressed lipids (19 sphingomyelins) in COPD, consequent to a diminished sex difference of sphingomyelins in COPD (false discovery rate [FDR] < 0.05, n = 44). Total, and some individual, fatty acid concentrations were greater in severe COPD than CON (FDR < 0.05, n = 16, d = 0.56–1.02). After adjusting for FEV(1)% predicted, we observed that grouped diacylglycerides (ρ = −0.745, FDR = 0.03) and triacylglycerides (ρ = −0.811, FDR = 0.01) were negatively associated with muscle oxidative capacity, but not physical activity, in severe COPD (n = 14). CONCLUSION: Strong negative associations relate impaired mitochondrial function to the accumulation of serum aclyglycerides in severe COPD. Lippincott Williams & Wilkins 2021-01 2020-07-17 /pmc/articles/PMC7737871/ /pubmed/32694368 http://dx.doi.org/10.1249/MSS.0000000000002441 Text en Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American College of Sports Medicine. This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. |
spellingShingle | Clinical Sciences LI, RONGSONG ADAMI, ALESSANDRA CHANG, CHIH-CHIANG TSENG, CHI-HONG HSIAI, TZUNG K. ROSSITER, HARRY B. Serum Acylglycerols Inversely Associate with Muscle Oxidative Capacity in Severe COPD |
title | Serum Acylglycerols Inversely Associate with Muscle Oxidative Capacity in Severe COPD |
title_full | Serum Acylglycerols Inversely Associate with Muscle Oxidative Capacity in Severe COPD |
title_fullStr | Serum Acylglycerols Inversely Associate with Muscle Oxidative Capacity in Severe COPD |
title_full_unstemmed | Serum Acylglycerols Inversely Associate with Muscle Oxidative Capacity in Severe COPD |
title_short | Serum Acylglycerols Inversely Associate with Muscle Oxidative Capacity in Severe COPD |
title_sort | serum acylglycerols inversely associate with muscle oxidative capacity in severe copd |
topic | Clinical Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737871/ https://www.ncbi.nlm.nih.gov/pubmed/32694368 http://dx.doi.org/10.1249/MSS.0000000000002441 |
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