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Congenital Zika syndrome: A systematic review
BACKGROUND: The signs and symptoms of Zika virus infection are usually mild and self-limited. However, the disease has been linked to neurological complications such as Guillain-Barré syndrome and peripheral nerve involvement, and also to abortion and fetal deaths due to vertical transmission, resul...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737899/ https://www.ncbi.nlm.nih.gov/pubmed/33320867 http://dx.doi.org/10.1371/journal.pone.0242367 |
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author | Freitas, Danielle A. Souza-Santos, Reinaldo Carvalho, Liege M. A. Barros, Wagner B. Neves, Luiza M. Brasil, Patrícia Wakimoto, Mayumi D. |
author_facet | Freitas, Danielle A. Souza-Santos, Reinaldo Carvalho, Liege M. A. Barros, Wagner B. Neves, Luiza M. Brasil, Patrícia Wakimoto, Mayumi D. |
author_sort | Freitas, Danielle A. |
collection | PubMed |
description | BACKGROUND: The signs and symptoms of Zika virus infection are usually mild and self-limited. However, the disease has been linked to neurological complications such as Guillain-Barré syndrome and peripheral nerve involvement, and also to abortion and fetal deaths due to vertical transmission, resulting in various congenital malformations in newborns, including microcephaly. This review aimed to describe the o signs and symptoms that characterize the congenital Zika syndrome. METHODS AND FINDINGS: A systematic review was performed with a protocol and described according to the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. The search strategy yielded 2,048 studies. After the exclusion of duplicates and application of inclusion criteria, 46 studies were included. The main signs and symptoms associated with the congenital Zika syndrome were microcephaly, parenchymal or cerebellar calcifications, ventriculomegaly, central nervous system hypoplasia or atrophy, arthrogryposis, ocular findings in the posterior and anterior segments, abnormal visual function and low birthweight for gestational age. CONCLUSIONS: Zika virus infection during pregnancy can cause a series of changes in the growth and development of children, while impacting the healthcare system due to the severity of cases. Our findings outline the disease profile in newborns and infants and may contribute to the development and updating of more specific clinical protocols. |
format | Online Article Text |
id | pubmed-7737899 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-77378992021-01-08 Congenital Zika syndrome: A systematic review Freitas, Danielle A. Souza-Santos, Reinaldo Carvalho, Liege M. A. Barros, Wagner B. Neves, Luiza M. Brasil, Patrícia Wakimoto, Mayumi D. PLoS One Research Article BACKGROUND: The signs and symptoms of Zika virus infection are usually mild and self-limited. However, the disease has been linked to neurological complications such as Guillain-Barré syndrome and peripheral nerve involvement, and also to abortion and fetal deaths due to vertical transmission, resulting in various congenital malformations in newborns, including microcephaly. This review aimed to describe the o signs and symptoms that characterize the congenital Zika syndrome. METHODS AND FINDINGS: A systematic review was performed with a protocol and described according to the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. The search strategy yielded 2,048 studies. After the exclusion of duplicates and application of inclusion criteria, 46 studies were included. The main signs and symptoms associated with the congenital Zika syndrome were microcephaly, parenchymal or cerebellar calcifications, ventriculomegaly, central nervous system hypoplasia or atrophy, arthrogryposis, ocular findings in the posterior and anterior segments, abnormal visual function and low birthweight for gestational age. CONCLUSIONS: Zika virus infection during pregnancy can cause a series of changes in the growth and development of children, while impacting the healthcare system due to the severity of cases. Our findings outline the disease profile in newborns and infants and may contribute to the development and updating of more specific clinical protocols. Public Library of Science 2020-12-15 /pmc/articles/PMC7737899/ /pubmed/33320867 http://dx.doi.org/10.1371/journal.pone.0242367 Text en © 2020 Freitas et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Freitas, Danielle A. Souza-Santos, Reinaldo Carvalho, Liege M. A. Barros, Wagner B. Neves, Luiza M. Brasil, Patrícia Wakimoto, Mayumi D. Congenital Zika syndrome: A systematic review |
title | Congenital Zika syndrome: A systematic review |
title_full | Congenital Zika syndrome: A systematic review |
title_fullStr | Congenital Zika syndrome: A systematic review |
title_full_unstemmed | Congenital Zika syndrome: A systematic review |
title_short | Congenital Zika syndrome: A systematic review |
title_sort | congenital zika syndrome: a systematic review |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7737899/ https://www.ncbi.nlm.nih.gov/pubmed/33320867 http://dx.doi.org/10.1371/journal.pone.0242367 |
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