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Efficacy of hydroxychloroquine in hand osteoarthritis: A protocol for systematic review and meta-analysis of randomized clinical trial

BACKGROUND: Symptoms of hand osteoarthritis result in activity limitations and lower quality of life. Hydroxychloroquine, which has been used successfully in the treatment of many autoimmune diseases, can suppress inflammation and might also be beneficial in hand osteoarthritis. METHODS: We plan to...

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Autores principales: Li, Qiang-Qiang, Xie, Ya-Dong, Liang, Wen-Qiang, Yang, Guo-Qing, Zhang, Huai-Bin, Wang, Yong-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738019/
https://www.ncbi.nlm.nih.gov/pubmed/33327296
http://dx.doi.org/10.1097/MD.0000000000023517
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author Li, Qiang-Qiang
Xie, Ya-Dong
Liang, Wen-Qiang
Yang, Guo-Qing
Zhang, Huai-Bin
Wang, Yong-Ping
author_facet Li, Qiang-Qiang
Xie, Ya-Dong
Liang, Wen-Qiang
Yang, Guo-Qing
Zhang, Huai-Bin
Wang, Yong-Ping
author_sort Li, Qiang-Qiang
collection PubMed
description BACKGROUND: Symptoms of hand osteoarthritis result in activity limitations and lower quality of life. Hydroxychloroquine, which has been used successfully in the treatment of many autoimmune diseases, can suppress inflammation and might also be beneficial in hand osteoarthritis. METHODS: We plan to perform a systematic review and meta-analysis of randomized clinical trial to determine the symptom-modifying effect of hydroxychloroquine in hand osteoarthritis. We will search PubMed, EMBASE, Cochrane Library, and Web of Science using a comprehensive strategy. The related conference proceedings and reference lists of the included studies will also be checked to identify additional studies. Two reviewers will screen retrieved records, extract information and assess the risk of bias independently. Stata v15.1 software will be used to conduct data synthesis. RESULTS: This study will be submitted to a peer-reviewed journal for publication. CONCLUSION: We hope it will provide a relatively comprehensive reference for clinical practice and future relevant clinical trials. INPLASY REGISTRATION NUMBER: INPLASY2020110005
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spelling pubmed-77380192020-12-16 Efficacy of hydroxychloroquine in hand osteoarthritis: A protocol for systematic review and meta-analysis of randomized clinical trial Li, Qiang-Qiang Xie, Ya-Dong Liang, Wen-Qiang Yang, Guo-Qing Zhang, Huai-Bin Wang, Yong-Ping Medicine (Baltimore) 6900 BACKGROUND: Symptoms of hand osteoarthritis result in activity limitations and lower quality of life. Hydroxychloroquine, which has been used successfully in the treatment of many autoimmune diseases, can suppress inflammation and might also be beneficial in hand osteoarthritis. METHODS: We plan to perform a systematic review and meta-analysis of randomized clinical trial to determine the symptom-modifying effect of hydroxychloroquine in hand osteoarthritis. We will search PubMed, EMBASE, Cochrane Library, and Web of Science using a comprehensive strategy. The related conference proceedings and reference lists of the included studies will also be checked to identify additional studies. Two reviewers will screen retrieved records, extract information and assess the risk of bias independently. Stata v15.1 software will be used to conduct data synthesis. RESULTS: This study will be submitted to a peer-reviewed journal for publication. CONCLUSION: We hope it will provide a relatively comprehensive reference for clinical practice and future relevant clinical trials. INPLASY REGISTRATION NUMBER: INPLASY2020110005 Lippincott Williams & Wilkins 2020-12-11 /pmc/articles/PMC7738019/ /pubmed/33327296 http://dx.doi.org/10.1097/MD.0000000000023517 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 6900
Li, Qiang-Qiang
Xie, Ya-Dong
Liang, Wen-Qiang
Yang, Guo-Qing
Zhang, Huai-Bin
Wang, Yong-Ping
Efficacy of hydroxychloroquine in hand osteoarthritis: A protocol for systematic review and meta-analysis of randomized clinical trial
title Efficacy of hydroxychloroquine in hand osteoarthritis: A protocol for systematic review and meta-analysis of randomized clinical trial
title_full Efficacy of hydroxychloroquine in hand osteoarthritis: A protocol for systematic review and meta-analysis of randomized clinical trial
title_fullStr Efficacy of hydroxychloroquine in hand osteoarthritis: A protocol for systematic review and meta-analysis of randomized clinical trial
title_full_unstemmed Efficacy of hydroxychloroquine in hand osteoarthritis: A protocol for systematic review and meta-analysis of randomized clinical trial
title_short Efficacy of hydroxychloroquine in hand osteoarthritis: A protocol for systematic review and meta-analysis of randomized clinical trial
title_sort efficacy of hydroxychloroquine in hand osteoarthritis: a protocol for systematic review and meta-analysis of randomized clinical trial
topic 6900
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738019/
https://www.ncbi.nlm.nih.gov/pubmed/33327296
http://dx.doi.org/10.1097/MD.0000000000023517
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