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Successful pregnancy and live birth in woman with congenital adrenal hyperplasia: A case report
RATIONALE: Women with congenital adrenal hyperplasia (CAH) can suffer from impaired fertility rates as a result of increased androgen secretion or impaired sex steroid production. CAH patients have lower pregnancy rate compared to normal women. Only a few cases with successful pregnancy have been re...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738089/ https://www.ncbi.nlm.nih.gov/pubmed/33327286 http://dx.doi.org/10.1097/MD.0000000000023495 |
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author | Xiong, Wei Huang, Guiqiong Wang, Xiaodong Tan, Shiqiao |
author_facet | Xiong, Wei Huang, Guiqiong Wang, Xiaodong Tan, Shiqiao |
author_sort | Xiong, Wei |
collection | PubMed |
description | RATIONALE: Women with congenital adrenal hyperplasia (CAH) can suffer from impaired fertility rates as a result of increased androgen secretion or impaired sex steroid production. CAH patients have lower pregnancy rate compared to normal women. Only a few cases with successful pregnancy have been reported in the literature. This report described a case of CAH with successful pregnancy and live birth. PATIENT CONCERNS: A 23-year-old woman visited our endocrinology department for clitoral hypertrophy and primary amenorrhea. DIAGNOSES: The patient was diagnosed as CAH. INTERVENTION: Prednisone was initially started to improve the patient's symptoms. Then she underwent clitoral resection and vaginoplasty several months later. She continuously took the prednisolone after the operation and had been undergoing regular checkups. OUTCOMES: She was pregnant spontaneously without assisted reproductive technology and had a successful live birth. Her baby had shown normal external genitalia with normal karyotype and normal development up to 6 years of age. LESSONS: Some mild CAH patients with certain types can achieved successful pregnancy without any assisted reproductive technology after treatment with steroid. The pregnancy rate among CAH women who wish to conceive may be much more optimistic than previous researches. |
format | Online Article Text |
id | pubmed-7738089 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-77380892020-12-16 Successful pregnancy and live birth in woman with congenital adrenal hyperplasia: A case report Xiong, Wei Huang, Guiqiong Wang, Xiaodong Tan, Shiqiao Medicine (Baltimore) 5600 RATIONALE: Women with congenital adrenal hyperplasia (CAH) can suffer from impaired fertility rates as a result of increased androgen secretion or impaired sex steroid production. CAH patients have lower pregnancy rate compared to normal women. Only a few cases with successful pregnancy have been reported in the literature. This report described a case of CAH with successful pregnancy and live birth. PATIENT CONCERNS: A 23-year-old woman visited our endocrinology department for clitoral hypertrophy and primary amenorrhea. DIAGNOSES: The patient was diagnosed as CAH. INTERVENTION: Prednisone was initially started to improve the patient's symptoms. Then she underwent clitoral resection and vaginoplasty several months later. She continuously took the prednisolone after the operation and had been undergoing regular checkups. OUTCOMES: She was pregnant spontaneously without assisted reproductive technology and had a successful live birth. Her baby had shown normal external genitalia with normal karyotype and normal development up to 6 years of age. LESSONS: Some mild CAH patients with certain types can achieved successful pregnancy without any assisted reproductive technology after treatment with steroid. The pregnancy rate among CAH women who wish to conceive may be much more optimistic than previous researches. Lippincott Williams & Wilkins 2020-12-11 /pmc/articles/PMC7738089/ /pubmed/33327286 http://dx.doi.org/10.1097/MD.0000000000023495 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 5600 Xiong, Wei Huang, Guiqiong Wang, Xiaodong Tan, Shiqiao Successful pregnancy and live birth in woman with congenital adrenal hyperplasia: A case report |
title | Successful pregnancy and live birth in woman with congenital adrenal hyperplasia: A case report |
title_full | Successful pregnancy and live birth in woman with congenital adrenal hyperplasia: A case report |
title_fullStr | Successful pregnancy and live birth in woman with congenital adrenal hyperplasia: A case report |
title_full_unstemmed | Successful pregnancy and live birth in woman with congenital adrenal hyperplasia: A case report |
title_short | Successful pregnancy and live birth in woman with congenital adrenal hyperplasia: A case report |
title_sort | successful pregnancy and live birth in woman with congenital adrenal hyperplasia: a case report |
topic | 5600 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738089/ https://www.ncbi.nlm.nih.gov/pubmed/33327286 http://dx.doi.org/10.1097/MD.0000000000023495 |
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