Cargando…
Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila
Increased cellular degradation by autophagy is a feature of many interventions that delay ageing. We report here that increased autophagy is necessary for reduced insulin-like signalling (IIS) to extend lifespan in Drosophila and is sufficient on its own to increase lifespan. We first established th...
| Autores principales: | , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738165/ https://www.ncbi.nlm.nih.gov/pubmed/33253201 http://dx.doi.org/10.1371/journal.pgen.1009083 |