Distinct insulin granule subpopulations implicated in the secretory pathology of diabetes types 1 and 2

Insulin secretion from β-cells is reduced at the onset of type-1 and during type-2 diabetes. Although inflammation and metabolic dysfunction of β-cells elicit secretory defects associated with type-1 or type-2 diabetes, accompanying changes to insulin granules have not been established. To address t...

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Detalles Bibliográficos
Autores principales: Kreutzberger, Alex J B, Kiessling, Volker, Doyle, Catherine A, Schenk, Noah, Upchurch, Clint M, Elmer-Dixon, Margaret, Ward, Amanda E, Preobraschenski, Julia, Hussein, Syed S, Tomaka, Weronika, Seelheim, Patrick, Kattan, Iman, Harris, Megan, Liang, Binyong, Kenworthy, Anne K, Desai, Bimal N, Leitinger, Norbert, Anantharam, Arun, Castle, J David, Tamm, Lukas K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738183/
https://www.ncbi.nlm.nih.gov/pubmed/33164744
http://dx.doi.org/10.7554/eLife.62506

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