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Ifit2 deficiency restricts microglial activation and leukocyte migration following murine coronavirus (m-CoV) CNS infection

The interferon-induced tetratricopeptide repeat protein (Ifit2) protects mice from lethal neurotropic viruses. Neurotropic coronavirus MHV-RSA59 infection of Ifit2(-/-) mice caused pronounced morbidity and mortality accompanied by rampant virus replication and spread throughout the brain. In spite o...

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Detalles Bibliográficos
Autores principales:	Das Sarma, Jayasri, Burrows, Amy, Rayman, Patricia, Hwang, Mi-Hyun, Kundu, Soumya, Sharma, Nikhil, Bergmann, Cornelia, Sen, Ganes C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738193/ https://www.ncbi.nlm.nih.gov/pubmed/33253295 http://dx.doi.org/10.1371/journal.ppat.1009034

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