Dammarane triterpenes targeting α-synuclein: biological activity and evaluation of binding sites by molecular docking

Parkinson's disease (PD) is a neurodegenerative disorder that affects adult people whose treatment is palliative. Thus, we decided to test three dammarane triterpenes 1, 1a, 1b, and we determined that 1 and 1a inhibit β-aggregation through thioflavine T rather than 1b. Since compound 1 was most...

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Detalles Bibliográficos
Autores principales: Cornejo, Alberto, Caballero, Julio, Simirgiotis, Mario, Torres, Vanessa, Sánchez, Luisa, Díaz, Nicolás, Guimaraes, Marcela, Hernández, Marcos, Areche, Carlos, Alfaro, Sergio, Caballero, Leonardo, Melo, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738290/
https://www.ncbi.nlm.nih.gov/pubmed/33307873
http://dx.doi.org/10.1080/14756366.2020.1851216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738290/
https://www.ncbi.nlm.nih.gov/pubmed/33307873
http://dx.doi.org/10.1080/14756366.2020.1851216

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