Cyclodextrin pendant polymer as an efficient drug carrier for scutellarin

A novel β-cyclodextrin pendant polymer (ε-PL-CD), composed of poly(ε-lysine) (ε-PL) main chain and glycine-β-cyclodextrin (Gly-CD) side chains, was prepared by a simple two-step procedure. The ε-PL-CD was investigated as a drug carrier of hydrophobic drug scutellarin (SCU). The characterization and...

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Autores principales: Liao, Rongqiang, Liu, Ying, Lv, Pin, Wu, Di, Xu, Meiling, Zheng, Xiaoyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738300/
https://www.ncbi.nlm.nih.gov/pubmed/33307844
http://dx.doi.org/10.1080/10717544.2020.1856223
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author Liao, Rongqiang
Liu, Ying
Lv, Pin
Wu, Di
Xu, Meiling
Zheng, Xiaoyuan
author_facet Liao, Rongqiang
Liu, Ying
Lv, Pin
Wu, Di
Xu, Meiling
Zheng, Xiaoyuan
author_sort Liao, Rongqiang
collection PubMed
description A novel β-cyclodextrin pendant polymer (ε-PL-CD), composed of poly(ε-lysine) (ε-PL) main chain and glycine-β-cyclodextrin (Gly-CD) side chains, was prepared by a simple two-step procedure. The ε-PL-CD was investigated as a drug carrier of hydrophobic drug scutellarin (SCU). The characterization and complexation mode of the SCU:ε-PL-CD were researched in both solution and solid state by means of photoluminescence spectroscopy, (1)H and 2D NMR, X-Ray powder diffraction (XRPD), thermal gravimetric analysis, Particle size and Zeta potential. The solubility test indicated that the solubilizing ability of SCU:ε-PL-CD was significantly improved compared with SCU:β-CD and free SCU. Besides, in vitro cell experiment, it was found that SCU:ε-PL-CD has a strong inhibitory effect on the growth and invasion of tumor cells. The present study provides useful information for ε-PL-CD as a drug carrier material.
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spelling pubmed-77383002020-12-21 Cyclodextrin pendant polymer as an efficient drug carrier for scutellarin Liao, Rongqiang Liu, Ying Lv, Pin Wu, Di Xu, Meiling Zheng, Xiaoyuan Drug Deliv Research Article A novel β-cyclodextrin pendant polymer (ε-PL-CD), composed of poly(ε-lysine) (ε-PL) main chain and glycine-β-cyclodextrin (Gly-CD) side chains, was prepared by a simple two-step procedure. The ε-PL-CD was investigated as a drug carrier of hydrophobic drug scutellarin (SCU). The characterization and complexation mode of the SCU:ε-PL-CD were researched in both solution and solid state by means of photoluminescence spectroscopy, (1)H and 2D NMR, X-Ray powder diffraction (XRPD), thermal gravimetric analysis, Particle size and Zeta potential. The solubility test indicated that the solubilizing ability of SCU:ε-PL-CD was significantly improved compared with SCU:β-CD and free SCU. Besides, in vitro cell experiment, it was found that SCU:ε-PL-CD has a strong inhibitory effect on the growth and invasion of tumor cells. The present study provides useful information for ε-PL-CD as a drug carrier material. Taylor & Francis 2020-12-13 /pmc/articles/PMC7738300/ /pubmed/33307844 http://dx.doi.org/10.1080/10717544.2020.1856223 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Liao, Rongqiang
Liu, Ying
Lv, Pin
Wu, Di
Xu, Meiling
Zheng, Xiaoyuan
Cyclodextrin pendant polymer as an efficient drug carrier for scutellarin
title Cyclodextrin pendant polymer as an efficient drug carrier for scutellarin
title_full Cyclodextrin pendant polymer as an efficient drug carrier for scutellarin
title_fullStr Cyclodextrin pendant polymer as an efficient drug carrier for scutellarin
title_full_unstemmed Cyclodextrin pendant polymer as an efficient drug carrier for scutellarin
title_short Cyclodextrin pendant polymer as an efficient drug carrier for scutellarin
title_sort cyclodextrin pendant polymer as an efficient drug carrier for scutellarin
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738300/
https://www.ncbi.nlm.nih.gov/pubmed/33307844
http://dx.doi.org/10.1080/10717544.2020.1856223
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