K(2P)2.1 (TREK-1) potassium channel activation protects against hyperoxia-induced lung injury

No targeted therapies exist to counteract Hyperoxia (HO)-induced Acute Lung Injury (HALI). We previously found that HO downregulates alveolar K(2P)2.1 (TREK-1) K(+) channels, which results in worsening lung injury. This decrease in TREK-1 levels leaves a subset of channels amendable to pharmacologic...

Descripción completa

Detalles Bibliográficos
Autores principales: Zyrianova, Tatiana, Lopez, Benjamin, Olcese, Riccardo, Belperio, John, Waters, Christopher M., Wong, Leanne, Nguyen, Victoria, Talapaneni, Sriharsha, Schwingshackl, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738539/
https://www.ncbi.nlm.nih.gov/pubmed/33319831
http://dx.doi.org/10.1038/s41598-020-78886-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738539/
https://www.ncbi.nlm.nih.gov/pubmed/33319831
http://dx.doi.org/10.1038/s41598-020-78886-y

Ejemplares similares