Intra-articular collagenase in the spinal facet joint induces pain, DRG neuron dysregulation and increased MMP-1 absent evidence of joint destruction

Degeneration is a hallmark of painful joint disease and is mediated by many proteases that degrade joint tissues, including collagenases. We hypothesized that purified bacterial collagenase would initiate nociceptive cascades in the joint by degrading the capsular ligament’s matrix and activating in...

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Detalles Bibliográficos
Autores principales: Ita, Meagan E., Ghimire, Prabesh, Welch, Rachel L., Troche, Harrison R., Winkelstein, Beth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738551/
https://www.ncbi.nlm.nih.gov/pubmed/33319791
http://dx.doi.org/10.1038/s41598-020-78811-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738551/
https://www.ncbi.nlm.nih.gov/pubmed/33319791
http://dx.doi.org/10.1038/s41598-020-78811-3

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