The Epigenetics of Glioma Stem Cells: A Brief Overview

Glioma stem cells (GSCs) are crucial in the formation, perpetuation and recurrence of glioblastomas (GBs) due to their self-renewal and proliferation properties. Although GSCs share cellular and molecular characteristics with neural stem cells (NSCs), GSCs show unique transcriptional and epigenetic...

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Detalles Bibliográficos
Autores principales: Valor, Luis M., Hervás-Corpión, Irati
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738619/
https://www.ncbi.nlm.nih.gov/pubmed/33344253
http://dx.doi.org/10.3389/fonc.2020.602378
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author Valor, Luis M.
Hervás-Corpión, Irati
author_facet Valor, Luis M.
Hervás-Corpión, Irati
author_sort Valor, Luis M.
collection PubMed
description Glioma stem cells (GSCs) are crucial in the formation, perpetuation and recurrence of glioblastomas (GBs) due to their self-renewal and proliferation properties. Although GSCs share cellular and molecular characteristics with neural stem cells (NSCs), GSCs show unique transcriptional and epigenetic features that may explain their relevant role in GB and may constitute druggable targets for novel therapeutic approaches. In this review, we will summarize the most important findings in GSCs concerning epigenetic-dependent mechanisms.
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spelling pubmed-77386192020-12-17 The Epigenetics of Glioma Stem Cells: A Brief Overview Valor, Luis M. Hervás-Corpión, Irati Front Oncol Oncology Glioma stem cells (GSCs) are crucial in the formation, perpetuation and recurrence of glioblastomas (GBs) due to their self-renewal and proliferation properties. Although GSCs share cellular and molecular characteristics with neural stem cells (NSCs), GSCs show unique transcriptional and epigenetic features that may explain their relevant role in GB and may constitute druggable targets for novel therapeutic approaches. In this review, we will summarize the most important findings in GSCs concerning epigenetic-dependent mechanisms. Frontiers Media S.A. 2020-12-02 /pmc/articles/PMC7738619/ /pubmed/33344253 http://dx.doi.org/10.3389/fonc.2020.602378 Text en Copyright © 2020 Valor and Hervás-Corpión http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Valor, Luis M.
Hervás-Corpión, Irati
The Epigenetics of Glioma Stem Cells: A Brief Overview
title The Epigenetics of Glioma Stem Cells: A Brief Overview
title_full The Epigenetics of Glioma Stem Cells: A Brief Overview
title_fullStr The Epigenetics of Glioma Stem Cells: A Brief Overview
title_full_unstemmed The Epigenetics of Glioma Stem Cells: A Brief Overview
title_short The Epigenetics of Glioma Stem Cells: A Brief Overview
title_sort epigenetics of glioma stem cells: a brief overview
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738619/
https://www.ncbi.nlm.nih.gov/pubmed/33344253
http://dx.doi.org/10.3389/fonc.2020.602378
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