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Multiplexed gene expression analysis of HLA class II-associated podoconiosis implicates chronic immune activation in its pathogenesis
BACKGROUND: Podoconiosis is a tropical lymphoedema of the leg resulting from barefoot exposure to irritant volcanic soils. Approximately 4 million people are affected, mainly in African highland regions. The pathogenesis of this neglected tropical disease is still largely unknown, although HLA class...
Autores principales: | Alcantara, Diana R, Jones, Christopher I, Altmann, Daniel M, Boyton, Rosemary J, Haniffa, Muzlifah, Newport, Melanie J |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738654/ https://www.ncbi.nlm.nih.gov/pubmed/33099652 http://dx.doi.org/10.1093/trstmh/traa107 |
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