The essential role of long non-coding RNA GAS5 in glioma: interaction with microRNAs, chemosensitivity and potential as a biomarker

Glioma is a malignant brain tumor with a generally poor prognosis. Dysregulation of a long non-coding RNA, GAS5, has been detected in numerous cancers, including glioma. Previous studies have suggested that GAS5 plays a significant functional role in glioma, affecting proliferation, metastasis, inva...

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Autores principales: Tan, Xuewen, Jiang, Haifeng, Fang, Yilong, Han, Dafei, Guo, Yawei, Wang, Xinming, Gong, Xun, Hong, Wenming, Tu, Jiajie, Wei, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738835/
https://www.ncbi.nlm.nih.gov/pubmed/33391419
http://dx.doi.org/10.7150/jca.49203
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author Tan, Xuewen
Jiang, Haifeng
Fang, Yilong
Han, Dafei
Guo, Yawei
Wang, Xinming
Gong, Xun
Hong, Wenming
Tu, Jiajie
Wei, Wei
author_facet Tan, Xuewen
Jiang, Haifeng
Fang, Yilong
Han, Dafei
Guo, Yawei
Wang, Xinming
Gong, Xun
Hong, Wenming
Tu, Jiajie
Wei, Wei
author_sort Tan, Xuewen
collection PubMed
description Glioma is a malignant brain tumor with a generally poor prognosis. Dysregulation of a long non-coding RNA, GAS5, has been detected in numerous cancers, including glioma. Previous studies have suggested that GAS5 plays a significant functional role in glioma, affecting proliferation, metastasis, invasion, and apoptosis. In this review, we describe the roles and mechanisms of GAS5 in glioma. GAS5 may be a biomarker for diagnosis and prognosis, and even a potential target for glioma treatment, and therefore warrants further investigation.
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spelling pubmed-77388352021-01-01 The essential role of long non-coding RNA GAS5 in glioma: interaction with microRNAs, chemosensitivity and potential as a biomarker Tan, Xuewen Jiang, Haifeng Fang, Yilong Han, Dafei Guo, Yawei Wang, Xinming Gong, Xun Hong, Wenming Tu, Jiajie Wei, Wei J Cancer Review Glioma is a malignant brain tumor with a generally poor prognosis. Dysregulation of a long non-coding RNA, GAS5, has been detected in numerous cancers, including glioma. Previous studies have suggested that GAS5 plays a significant functional role in glioma, affecting proliferation, metastasis, invasion, and apoptosis. In this review, we describe the roles and mechanisms of GAS5 in glioma. GAS5 may be a biomarker for diagnosis and prognosis, and even a potential target for glioma treatment, and therefore warrants further investigation. Ivyspring International Publisher 2021-01-01 /pmc/articles/PMC7738835/ /pubmed/33391419 http://dx.doi.org/10.7150/jca.49203 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Tan, Xuewen
Jiang, Haifeng
Fang, Yilong
Han, Dafei
Guo, Yawei
Wang, Xinming
Gong, Xun
Hong, Wenming
Tu, Jiajie
Wei, Wei
The essential role of long non-coding RNA GAS5 in glioma: interaction with microRNAs, chemosensitivity and potential as a biomarker
title The essential role of long non-coding RNA GAS5 in glioma: interaction with microRNAs, chemosensitivity and potential as a biomarker
title_full The essential role of long non-coding RNA GAS5 in glioma: interaction with microRNAs, chemosensitivity and potential as a biomarker
title_fullStr The essential role of long non-coding RNA GAS5 in glioma: interaction with microRNAs, chemosensitivity and potential as a biomarker
title_full_unstemmed The essential role of long non-coding RNA GAS5 in glioma: interaction with microRNAs, chemosensitivity and potential as a biomarker
title_short The essential role of long non-coding RNA GAS5 in glioma: interaction with microRNAs, chemosensitivity and potential as a biomarker
title_sort essential role of long non-coding rna gas5 in glioma: interaction with micrornas, chemosensitivity and potential as a biomarker
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738835/
https://www.ncbi.nlm.nih.gov/pubmed/33391419
http://dx.doi.org/10.7150/jca.49203
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