Covalent modification of Keap1 at Cys77 and Cys434 by pubescenoside a suppresses oxidative stress-induced NLRP3 inflammasome activation in myocardial ischemia-reperfusion injury

Background and Purpose: Kelch ECH-associating protein 1 (Keap1) is a crucial chaperonin for E3 ubiquitin ligases. Modification of the key reactive cysteine residues in Keap1 affects the interaction between Keap1 and its substrate nuclear factor erythroid 2-related factor 2 (Nrf2), subsequently regul...

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Detalles Bibliográficos
Autores principales: Cheng, Yuanyuan, Cheng, Liangkai, Gao, Xiang, Chen, Sixuan, Wu, Peng, Wang, Caiyan, Liu, Zhongqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738871/
https://www.ncbi.nlm.nih.gov/pubmed/33391509
http://dx.doi.org/10.7150/thno.48436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738871/
https://www.ncbi.nlm.nih.gov/pubmed/33391509
http://dx.doi.org/10.7150/thno.48436

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