Identification of novel CD44v6-binding peptides that block CD44v6 and deliver a pro-apoptotic peptide to tumors to inhibit tumor growth and metastasis in mice

CD44v6, a splice variant of the cell surface glycoprotein CD44, acts as a co-receptor for c-Met and is upregulated in tumors with high metastatic potential. Methods: We screened a phage-displayed peptide library for peptides that selectively bind to CD44v6-overexpressing cells and exploited them to...

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Detalles Bibliográficos
Autores principales: Khan, Fatima, Gurung, Smriti, Gunassekaran, Gowri Rangaswamy, Vadevoo, Sri Murugan Poongkavithai, Chi, Lianhua, Permpoon, Uttapol, Haque, Md. Enamul, Lee, Yun-Ki, Lee, Soo-Woong, Kim, Soyoun, Lee, Byungheon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738880/
https://www.ncbi.nlm.nih.gov/pubmed/33391537
http://dx.doi.org/10.7150/thno.50564

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