Tofacitinib restores the balance of γδTreg/γδT17 cells in rheumatoid arthritis by inhibiting the NLRP3 inflammasome

Objective: Tofacitinib (TOF) is a Janus kinase (JAK) inhibitor used in the treatment of rheumatoid arthritis (RA), but the mechanism of its action remains unclear. In this study, we investigated the influence of TOF on gamma delta regulatory T-cell (γδTreg)/γδT17 cell balance in RA and the role of t...

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Detalles Bibliográficos
Autores principales: Yang, Xinyu, Zhan, Ning, Jin, Yang, Ling, Hanzhi, Xiao, Chipeng, Xie, Zhen, Zhong, Hao, Yu, Xinxin, Tang, Runhua, Ma, Jinglan, Guan, Jubo, Yin, Guoyu, Wu, Gan, Lu, Liangjing, Wang, Jianguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738886/
https://www.ncbi.nlm.nih.gov/pubmed/33391544
http://dx.doi.org/10.7150/thno.47860

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