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Apolipoprotein E, low-density lipoprotein receptor, and immune cells control blood-brain barrier penetration by AAV-PHP.eB in mice

Rationale: The blood-brain barrier (BBB) prevents the effective delivery of therapeutic molecules to the central nervous system (CNS). A recently generated adeno-associated virus (AAV)-based vector, AAV-PHP.eB, has been found to penetrate the BBB more efficiently than other vectors including AAV-PHP...

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Detalles Bibliográficos
Autores principales:	Xie, Bao-Shu, Wang, Xin, Pan, Yao-Hua, Jiang, Gan, Feng, Jun-Feng, Lin, Yong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738887/ https://www.ncbi.nlm.nih.gov/pubmed/33391529 http://dx.doi.org/10.7150/thno.46992

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