Intranasal vaccination with a lentiviral vector protects against SARS-CoV-2 in preclinical animal models

To develop a vaccine candidate against coronavirus disease 2019 (COVID-19), we generated a lentiviral vector (LV) eliciting neutralizing antibodies against the Spike glycoprotein of SARS-CoV-2. Systemic vaccination by this vector in mice, in which the expression of the SARS-CoV-2 receptor hACE2 has...

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Detalles Bibliográficos
Autores principales: Ku, Min-Wen, Bourgine, Maryline, Authié, Pierre, Lopez, Jodie, Nemirov, Kirill, Moncoq, Fanny, Noirat, Amandine, Vesin, Benjamin, Nevo, Fabien, Blanc, Catherine, Souque, Philippe, Tabbal, Houda, Simon, Emeline, Hardy, David, Le Dudal, Marine, Guinet, Françoise, Fiette, Laurence, Mouquet, Hugo, Anna, François, Martin, Annette, Escriou, Nicolas, Majlessi, Laleh, Charneau, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738935/
https://www.ncbi.nlm.nih.gov/pubmed/33357418
http://dx.doi.org/10.1016/j.chom.2020.12.010

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