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Clinicopathological characteristics and prognosis of 77 cases with type 3 gastric neuroendocrine tumours

BACKGROUND: For the rarity of type 3 gastric neuroendocrine tumours (g-NETs), their clinicopathological characteristics and prognosis are not well illustrated. AIM: To describe the clinicopathological features and outcome of type 3 g-NETs in the Chinese population. METHODS: Based on the 2019 WHO pat...

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Autores principales: Li, Yuan-Liang, Qiu, Xu-Dong, Chen, Jie, Zhang, Yu, Li, Jie, Xu, Jian-Ming, Wang, Chao, Qi, Zhi-Rong, Luo, Jie, Tan, Huang-Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7739150/
https://www.ncbi.nlm.nih.gov/pubmed/33362912
http://dx.doi.org/10.4251/wjgo.v12.i12.1416
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author Li, Yuan-Liang
Qiu, Xu-Dong
Chen, Jie
Zhang, Yu
Li, Jie
Xu, Jian-Ming
Wang, Chao
Qi, Zhi-Rong
Luo, Jie
Tan, Huang-Ying
author_facet Li, Yuan-Liang
Qiu, Xu-Dong
Chen, Jie
Zhang, Yu
Li, Jie
Xu, Jian-Ming
Wang, Chao
Qi, Zhi-Rong
Luo, Jie
Tan, Huang-Ying
author_sort Li, Yuan-Liang
collection PubMed
description BACKGROUND: For the rarity of type 3 gastric neuroendocrine tumours (g-NETs), their clinicopathological characteristics and prognosis are not well illustrated. AIM: To describe the clinicopathological features and outcome of type 3 g-NETs in the Chinese population. METHODS: Based on the 2019 WHO pathological classification, the clinicopathological characteristics and prognosis of patients with type 3 g-NETs in China were retrospectively analysed. RESULTS: A total of 77 patients (55.8% of females) with type 3 g-NETs were analysed, with a median age of 48 years (range: 28-79 years). The tumours were mainly located in the gastric fundus/body (83.1%) and were mostly solitary (83.1%), with a median size of 1.5 cm (0.8-3.5 cm). Of these, there were 37 G1 tumours (48.1%), 31 G2 (40.3%), and 9 G3 (11.7%). Ten (13.0%) and 24 (31.2%) patients had lymph node and distant metastasis, respectively. In addition, type 3 g-NETs were heterogeneous. Compared with G1 NETs, G2 NETs had a higher lymph node metastasis rate, and G3 NETs had a higher distant metastasis rate. G1 and G2 NETs with stage I/II disease (33/68) received endoscopic treatment, and no tumour recurrence or tumour-related death was observed within a median follow-up time of 36 mo. Grade and distant metastasis were identified to be independent risk factors for prognosis in multivariable analysis. CONCLUSION: Type 3 g-NETs are obviously heterogeneous, and the updated WHO 2019 pathological classification may be used to effectively evaluate their biological behaviors and prognosis. Also, endoscopic treatment should be considered for small (< 2 cm), low grade, superficial tumours.
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spelling pubmed-77391502020-12-24 Clinicopathological characteristics and prognosis of 77 cases with type 3 gastric neuroendocrine tumours Li, Yuan-Liang Qiu, Xu-Dong Chen, Jie Zhang, Yu Li, Jie Xu, Jian-Ming Wang, Chao Qi, Zhi-Rong Luo, Jie Tan, Huang-Ying World J Gastrointest Oncol Retrospective Study BACKGROUND: For the rarity of type 3 gastric neuroendocrine tumours (g-NETs), their clinicopathological characteristics and prognosis are not well illustrated. AIM: To describe the clinicopathological features and outcome of type 3 g-NETs in the Chinese population. METHODS: Based on the 2019 WHO pathological classification, the clinicopathological characteristics and prognosis of patients with type 3 g-NETs in China were retrospectively analysed. RESULTS: A total of 77 patients (55.8% of females) with type 3 g-NETs were analysed, with a median age of 48 years (range: 28-79 years). The tumours were mainly located in the gastric fundus/body (83.1%) and were mostly solitary (83.1%), with a median size of 1.5 cm (0.8-3.5 cm). Of these, there were 37 G1 tumours (48.1%), 31 G2 (40.3%), and 9 G3 (11.7%). Ten (13.0%) and 24 (31.2%) patients had lymph node and distant metastasis, respectively. In addition, type 3 g-NETs were heterogeneous. Compared with G1 NETs, G2 NETs had a higher lymph node metastasis rate, and G3 NETs had a higher distant metastasis rate. G1 and G2 NETs with stage I/II disease (33/68) received endoscopic treatment, and no tumour recurrence or tumour-related death was observed within a median follow-up time of 36 mo. Grade and distant metastasis were identified to be independent risk factors for prognosis in multivariable analysis. CONCLUSION: Type 3 g-NETs are obviously heterogeneous, and the updated WHO 2019 pathological classification may be used to effectively evaluate their biological behaviors and prognosis. Also, endoscopic treatment should be considered for small (< 2 cm), low grade, superficial tumours. Baishideng Publishing Group Inc 2020-12-15 2020-12-15 /pmc/articles/PMC7739150/ /pubmed/33362912 http://dx.doi.org/10.4251/wjgo.v12.i12.1416 Text en ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Noncommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Retrospective Study
Li, Yuan-Liang
Qiu, Xu-Dong
Chen, Jie
Zhang, Yu
Li, Jie
Xu, Jian-Ming
Wang, Chao
Qi, Zhi-Rong
Luo, Jie
Tan, Huang-Ying
Clinicopathological characteristics and prognosis of 77 cases with type 3 gastric neuroendocrine tumours
title Clinicopathological characteristics and prognosis of 77 cases with type 3 gastric neuroendocrine tumours
title_full Clinicopathological characteristics and prognosis of 77 cases with type 3 gastric neuroendocrine tumours
title_fullStr Clinicopathological characteristics and prognosis of 77 cases with type 3 gastric neuroendocrine tumours
title_full_unstemmed Clinicopathological characteristics and prognosis of 77 cases with type 3 gastric neuroendocrine tumours
title_short Clinicopathological characteristics and prognosis of 77 cases with type 3 gastric neuroendocrine tumours
title_sort clinicopathological characteristics and prognosis of 77 cases with type 3 gastric neuroendocrine tumours
topic Retrospective Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7739150/
https://www.ncbi.nlm.nih.gov/pubmed/33362912
http://dx.doi.org/10.4251/wjgo.v12.i12.1416
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