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Clinicopathological characteristics and prognosis of 77 cases with type 3 gastric neuroendocrine tumours
BACKGROUND: For the rarity of type 3 gastric neuroendocrine tumours (g-NETs), their clinicopathological characteristics and prognosis are not well illustrated. AIM: To describe the clinicopathological features and outcome of type 3 g-NETs in the Chinese population. METHODS: Based on the 2019 WHO pat...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7739150/ https://www.ncbi.nlm.nih.gov/pubmed/33362912 http://dx.doi.org/10.4251/wjgo.v12.i12.1416 |
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author | Li, Yuan-Liang Qiu, Xu-Dong Chen, Jie Zhang, Yu Li, Jie Xu, Jian-Ming Wang, Chao Qi, Zhi-Rong Luo, Jie Tan, Huang-Ying |
author_facet | Li, Yuan-Liang Qiu, Xu-Dong Chen, Jie Zhang, Yu Li, Jie Xu, Jian-Ming Wang, Chao Qi, Zhi-Rong Luo, Jie Tan, Huang-Ying |
author_sort | Li, Yuan-Liang |
collection | PubMed |
description | BACKGROUND: For the rarity of type 3 gastric neuroendocrine tumours (g-NETs), their clinicopathological characteristics and prognosis are not well illustrated. AIM: To describe the clinicopathological features and outcome of type 3 g-NETs in the Chinese population. METHODS: Based on the 2019 WHO pathological classification, the clinicopathological characteristics and prognosis of patients with type 3 g-NETs in China were retrospectively analysed. RESULTS: A total of 77 patients (55.8% of females) with type 3 g-NETs were analysed, with a median age of 48 years (range: 28-79 years). The tumours were mainly located in the gastric fundus/body (83.1%) and were mostly solitary (83.1%), with a median size of 1.5 cm (0.8-3.5 cm). Of these, there were 37 G1 tumours (48.1%), 31 G2 (40.3%), and 9 G3 (11.7%). Ten (13.0%) and 24 (31.2%) patients had lymph node and distant metastasis, respectively. In addition, type 3 g-NETs were heterogeneous. Compared with G1 NETs, G2 NETs had a higher lymph node metastasis rate, and G3 NETs had a higher distant metastasis rate. G1 and G2 NETs with stage I/II disease (33/68) received endoscopic treatment, and no tumour recurrence or tumour-related death was observed within a median follow-up time of 36 mo. Grade and distant metastasis were identified to be independent risk factors for prognosis in multivariable analysis. CONCLUSION: Type 3 g-NETs are obviously heterogeneous, and the updated WHO 2019 pathological classification may be used to effectively evaluate their biological behaviors and prognosis. Also, endoscopic treatment should be considered for small (< 2 cm), low grade, superficial tumours. |
format | Online Article Text |
id | pubmed-7739150 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-77391502020-12-24 Clinicopathological characteristics and prognosis of 77 cases with type 3 gastric neuroendocrine tumours Li, Yuan-Liang Qiu, Xu-Dong Chen, Jie Zhang, Yu Li, Jie Xu, Jian-Ming Wang, Chao Qi, Zhi-Rong Luo, Jie Tan, Huang-Ying World J Gastrointest Oncol Retrospective Study BACKGROUND: For the rarity of type 3 gastric neuroendocrine tumours (g-NETs), their clinicopathological characteristics and prognosis are not well illustrated. AIM: To describe the clinicopathological features and outcome of type 3 g-NETs in the Chinese population. METHODS: Based on the 2019 WHO pathological classification, the clinicopathological characteristics and prognosis of patients with type 3 g-NETs in China were retrospectively analysed. RESULTS: A total of 77 patients (55.8% of females) with type 3 g-NETs were analysed, with a median age of 48 years (range: 28-79 years). The tumours were mainly located in the gastric fundus/body (83.1%) and were mostly solitary (83.1%), with a median size of 1.5 cm (0.8-3.5 cm). Of these, there were 37 G1 tumours (48.1%), 31 G2 (40.3%), and 9 G3 (11.7%). Ten (13.0%) and 24 (31.2%) patients had lymph node and distant metastasis, respectively. In addition, type 3 g-NETs were heterogeneous. Compared with G1 NETs, G2 NETs had a higher lymph node metastasis rate, and G3 NETs had a higher distant metastasis rate. G1 and G2 NETs with stage I/II disease (33/68) received endoscopic treatment, and no tumour recurrence or tumour-related death was observed within a median follow-up time of 36 mo. Grade and distant metastasis were identified to be independent risk factors for prognosis in multivariable analysis. CONCLUSION: Type 3 g-NETs are obviously heterogeneous, and the updated WHO 2019 pathological classification may be used to effectively evaluate their biological behaviors and prognosis. Also, endoscopic treatment should be considered for small (< 2 cm), low grade, superficial tumours. Baishideng Publishing Group Inc 2020-12-15 2020-12-15 /pmc/articles/PMC7739150/ /pubmed/33362912 http://dx.doi.org/10.4251/wjgo.v12.i12.1416 Text en ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Noncommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Retrospective Study Li, Yuan-Liang Qiu, Xu-Dong Chen, Jie Zhang, Yu Li, Jie Xu, Jian-Ming Wang, Chao Qi, Zhi-Rong Luo, Jie Tan, Huang-Ying Clinicopathological characteristics and prognosis of 77 cases with type 3 gastric neuroendocrine tumours |
title | Clinicopathological characteristics and prognosis of 77 cases with type 3 gastric neuroendocrine tumours |
title_full | Clinicopathological characteristics and prognosis of 77 cases with type 3 gastric neuroendocrine tumours |
title_fullStr | Clinicopathological characteristics and prognosis of 77 cases with type 3 gastric neuroendocrine tumours |
title_full_unstemmed | Clinicopathological characteristics and prognosis of 77 cases with type 3 gastric neuroendocrine tumours |
title_short | Clinicopathological characteristics and prognosis of 77 cases with type 3 gastric neuroendocrine tumours |
title_sort | clinicopathological characteristics and prognosis of 77 cases with type 3 gastric neuroendocrine tumours |
topic | Retrospective Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7739150/ https://www.ncbi.nlm.nih.gov/pubmed/33362912 http://dx.doi.org/10.4251/wjgo.v12.i12.1416 |
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