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Asthaxanthin Improves Aerobic Exercise Recovery Without Affecting Heat Tolerance in Humans
Objectives: To examine the supplementation effects of the xanthophyll carotenoid Astaxanthin on physical performance and exertional heat strain in humans. Design: A randomized double blind placebo controlled trial. Methods: Twenty two male participants (Age: 23.14 ± 3.5 y, height: 175 ± 6 cm, body m...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7739736/ https://www.ncbi.nlm.nih.gov/pubmed/33344941 http://dx.doi.org/10.3389/fspor.2019.00017 |
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author | Fleischmann, Chen Horowitz, Michal Yanovich, Ran Raz, Hany Heled, Yuval |
author_facet | Fleischmann, Chen Horowitz, Michal Yanovich, Ran Raz, Hany Heled, Yuval |
author_sort | Fleischmann, Chen |
collection | PubMed |
description | Objectives: To examine the supplementation effects of the xanthophyll carotenoid Astaxanthin on physical performance and exertional heat strain in humans. Design: A randomized double blind placebo controlled trial. Methods: Twenty two male participants (Age: 23.14 ± 3.5 y, height: 175 ± 6 cm, body mass: 69.6 ± 8.7 kg, % body fat: 16.8 ± 3.8) received placebo (PLA, n = 10) or Astaxanthin (ATX, n = 12) 12 mg/day Per os (P.O), for 30 days, and were tested pre and post-supplementation with a maximal oxygen uptake (VO(2) Max) test and the heat tolerance test (HTT) (2 h walk at 40°C, 40% relative humidity (RH), 5 kph, 2% incline). NIH database registration no. NCT02088242. Gas exchange, Heart rate (HR), Relative perceived exertion (RPE), and blood lactate were measured during the VO(2) Max test. Heart rate (HR), rectal (Trec), and skin (Tskin) temperatures, RPE, and sweat rate (SR) were monitored in the HTT. Serum heat shock protein 72 (HSP72), Creatine phospho-kinase (CPK), C-reactive protein (CRP), and lipid profile were measured before and after the test. Results: The rise in blood lactate caused by the VO(2) Max test was significantly diminished in the ATX group (9.4 ± 3.1 and 13.0 ± 3.1 mmole(*)l(−1) in the ATX and PLA groups, respectively P < 0.02), as was the change in oxygen uptake during recovery (−2.02 ± 0.64 and 0.83 ± 0.79% of VO(2) Max in the ATX and PLA group, respectively, p = 0.001). No significant differences were observed in the anaerobic threshold or VO(2) Max. In the HTT, no significant physiological or biochemical differences were observed (HR <120 bpm, Trec rose by ~1°C to <38°C, no difference in SR). Conclusions: Astaxanthin supplementation improved exercise recovery. No benefit was observed for ATX over PLA in response to heat stress. Further examination of Astaxanthin in higher exertional heat strain is required. |
format | Online Article Text |
id | pubmed-7739736 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-77397362020-12-17 Asthaxanthin Improves Aerobic Exercise Recovery Without Affecting Heat Tolerance in Humans Fleischmann, Chen Horowitz, Michal Yanovich, Ran Raz, Hany Heled, Yuval Front Sports Act Living Sports and Active Living Objectives: To examine the supplementation effects of the xanthophyll carotenoid Astaxanthin on physical performance and exertional heat strain in humans. Design: A randomized double blind placebo controlled trial. Methods: Twenty two male participants (Age: 23.14 ± 3.5 y, height: 175 ± 6 cm, body mass: 69.6 ± 8.7 kg, % body fat: 16.8 ± 3.8) received placebo (PLA, n = 10) or Astaxanthin (ATX, n = 12) 12 mg/day Per os (P.O), for 30 days, and were tested pre and post-supplementation with a maximal oxygen uptake (VO(2) Max) test and the heat tolerance test (HTT) (2 h walk at 40°C, 40% relative humidity (RH), 5 kph, 2% incline). NIH database registration no. NCT02088242. Gas exchange, Heart rate (HR), Relative perceived exertion (RPE), and blood lactate were measured during the VO(2) Max test. Heart rate (HR), rectal (Trec), and skin (Tskin) temperatures, RPE, and sweat rate (SR) were monitored in the HTT. Serum heat shock protein 72 (HSP72), Creatine phospho-kinase (CPK), C-reactive protein (CRP), and lipid profile were measured before and after the test. Results: The rise in blood lactate caused by the VO(2) Max test was significantly diminished in the ATX group (9.4 ± 3.1 and 13.0 ± 3.1 mmole(*)l(−1) in the ATX and PLA groups, respectively P < 0.02), as was the change in oxygen uptake during recovery (−2.02 ± 0.64 and 0.83 ± 0.79% of VO(2) Max in the ATX and PLA group, respectively, p = 0.001). No significant differences were observed in the anaerobic threshold or VO(2) Max. In the HTT, no significant physiological or biochemical differences were observed (HR <120 bpm, Trec rose by ~1°C to <38°C, no difference in SR). Conclusions: Astaxanthin supplementation improved exercise recovery. No benefit was observed for ATX over PLA in response to heat stress. Further examination of Astaxanthin in higher exertional heat strain is required. Frontiers Media S.A. 2019-09-04 /pmc/articles/PMC7739736/ /pubmed/33344941 http://dx.doi.org/10.3389/fspor.2019.00017 Text en Copyright © 2019 Fleischmann, Horowitz, Yanovich, Raz and Heled. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Sports and Active Living Fleischmann, Chen Horowitz, Michal Yanovich, Ran Raz, Hany Heled, Yuval Asthaxanthin Improves Aerobic Exercise Recovery Without Affecting Heat Tolerance in Humans |
title | Asthaxanthin Improves Aerobic Exercise Recovery Without Affecting Heat Tolerance in Humans |
title_full | Asthaxanthin Improves Aerobic Exercise Recovery Without Affecting Heat Tolerance in Humans |
title_fullStr | Asthaxanthin Improves Aerobic Exercise Recovery Without Affecting Heat Tolerance in Humans |
title_full_unstemmed | Asthaxanthin Improves Aerobic Exercise Recovery Without Affecting Heat Tolerance in Humans |
title_short | Asthaxanthin Improves Aerobic Exercise Recovery Without Affecting Heat Tolerance in Humans |
title_sort | asthaxanthin improves aerobic exercise recovery without affecting heat tolerance in humans |
topic | Sports and Active Living |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7739736/ https://www.ncbi.nlm.nih.gov/pubmed/33344941 http://dx.doi.org/10.3389/fspor.2019.00017 |
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