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Robust folding of a de novo designed ideal protein even with most of the core mutated to valine
Protein design provides a stringent test for our understanding of protein folding. We previously described principles for designing ideal protein structures stabilized by consistent local and nonlocal interactions, based on a set of rules relating local backbone structures to tertiary packing motifs...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7739874/ https://www.ncbi.nlm.nih.gov/pubmed/33229587 http://dx.doi.org/10.1073/pnas.2002120117 |