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Towards blood flow in the virtual human: efficient self-coupling of HemeLB

Many scientific and medical researchers are working towards the creation of a virtual human—a personalized digital copy of an individual—that will assist in a patient’s diagnosis, treatment and recovery. The complex nature of living systems means that the development of this remains a major challeng...

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Autores principales: McCullough, J. W. S., Richardson, R. A., Patronis, A., Halver, R., Marshall, R., Ruefenacht, M., Wylie, B. J. N., Odaker, T., Wiedemann, M., Lloyd, B., Neufeld, E., Sutmann, G., Skjellum, A., Kranzlmüller, D., Coveney, P. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7739917/
https://www.ncbi.nlm.nih.gov/pubmed/33335704
http://dx.doi.org/10.1098/rsfs.2019.0119
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author McCullough, J. W. S.
Richardson, R. A.
Patronis, A.
Halver, R.
Marshall, R.
Ruefenacht, M.
Wylie, B. J. N.
Odaker, T.
Wiedemann, M.
Lloyd, B.
Neufeld, E.
Sutmann, G.
Skjellum, A.
Kranzlmüller, D.
Coveney, P. V.
author_facet McCullough, J. W. S.
Richardson, R. A.
Patronis, A.
Halver, R.
Marshall, R.
Ruefenacht, M.
Wylie, B. J. N.
Odaker, T.
Wiedemann, M.
Lloyd, B.
Neufeld, E.
Sutmann, G.
Skjellum, A.
Kranzlmüller, D.
Coveney, P. V.
author_sort McCullough, J. W. S.
collection PubMed
description Many scientific and medical researchers are working towards the creation of a virtual human—a personalized digital copy of an individual—that will assist in a patient’s diagnosis, treatment and recovery. The complex nature of living systems means that the development of this remains a major challenge. We describe progress in enabling the HemeLB lattice Boltzmann code to simulate 3D macroscopic blood flow on a full human scale. Significant developments in memory management and load balancing allow near linear scaling performance of the code on hundreds of thousands of computer cores. Integral to the construction of a virtual human, we also outline the implementation of a self-coupling strategy for HemeLB. This allows simultaneous simulation of arterial and venous vascular trees based on human-specific geometries.
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spelling pubmed-77399172020-12-16 Towards blood flow in the virtual human: efficient self-coupling of HemeLB McCullough, J. W. S. Richardson, R. A. Patronis, A. Halver, R. Marshall, R. Ruefenacht, M. Wylie, B. J. N. Odaker, T. Wiedemann, M. Lloyd, B. Neufeld, E. Sutmann, G. Skjellum, A. Kranzlmüller, D. Coveney, P. V. Interface Focus Articles Many scientific and medical researchers are working towards the creation of a virtual human—a personalized digital copy of an individual—that will assist in a patient’s diagnosis, treatment and recovery. The complex nature of living systems means that the development of this remains a major challenge. We describe progress in enabling the HemeLB lattice Boltzmann code to simulate 3D macroscopic blood flow on a full human scale. Significant developments in memory management and load balancing allow near linear scaling performance of the code on hundreds of thousands of computer cores. Integral to the construction of a virtual human, we also outline the implementation of a self-coupling strategy for HemeLB. This allows simultaneous simulation of arterial and venous vascular trees based on human-specific geometries. The Royal Society 2021-02-06 2020-12-11 /pmc/articles/PMC7739917/ /pubmed/33335704 http://dx.doi.org/10.1098/rsfs.2019.0119 Text en © 2020 The Authors. http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/http://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Articles
McCullough, J. W. S.
Richardson, R. A.
Patronis, A.
Halver, R.
Marshall, R.
Ruefenacht, M.
Wylie, B. J. N.
Odaker, T.
Wiedemann, M.
Lloyd, B.
Neufeld, E.
Sutmann, G.
Skjellum, A.
Kranzlmüller, D.
Coveney, P. V.
Towards blood flow in the virtual human: efficient self-coupling of HemeLB
title Towards blood flow in the virtual human: efficient self-coupling of HemeLB
title_full Towards blood flow in the virtual human: efficient self-coupling of HemeLB
title_fullStr Towards blood flow in the virtual human: efficient self-coupling of HemeLB
title_full_unstemmed Towards blood flow in the virtual human: efficient self-coupling of HemeLB
title_short Towards blood flow in the virtual human: efficient self-coupling of HemeLB
title_sort towards blood flow in the virtual human: efficient self-coupling of hemelb
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7739917/
https://www.ncbi.nlm.nih.gov/pubmed/33335704
http://dx.doi.org/10.1098/rsfs.2019.0119
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